Background and Objectives: Cardiovascular diseases especially atherosclerosis, are the main cause of disability and death in all over the world and they have been on the rise in Iran. C-Reactive protein and Lipid profile are risk factors for prediction of atherosclerosis. Aerobic training and Grape seed extract has a very high potential in reducing or inhibiting hs-crp and lipid profile. The main aim of this study is to determine the effect of aerobic training and grape seed extract on some cardiovascular risk indexes in young men.

Materials & Methods: In this study,40 healthy non-athlete men with an average age of 22.60±0.98 years, body mass index of 24.15±1.58 kg.m² and body fat present of 18.06±1.64 were randomly divided into four groups of training-supplement (n=10), training-placebo (n=10), supplement (n=10) and placebo (n=10). Aerobic training program consists of three sessions of running per week with 60-85 percent target heart rate for 8 weeks. Before and after the intervention, hs-CRP, TC, TG , HDL-C and LDL-C were measured. Data were statistically analyzed by one-way ANOVA and post-hoc Tukey methods (p<0.05).

Results: The results showed that aerobic training along with grape seed extract consumption significantly reduced  hs-crp, TG(except training-placebo group),TC, LDL-C and significantly increased HDL-C  in training–supplement, training-placebo  and supplement group(P< 0.05). However, no significant change was observed in the control group (P> 0.05).

Conclusion: The results showed that 8 weeks of aerobic training either alone (training - placebo) or in combination with grape seed extract (training - supplement) and grape seed extract alone consumption (supplement),reduce cardiovascular risk factors in young men.