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Effect of alpha-lipoic acid supplementation on anthropometric indices, hypertension, and food intake in male patients with chronic spinal cord injury
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V Mohammadi   , Sh Eghtesadi * , M Khalili , Sh Jazayeri , H Saberi , S Keshtkar Aghababaee , H Sabour , MR Gohari , F Ghaderi |
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Abstract: (14356 Views) |
| Background and objective: Alpha-lipoic acid, a cofactor in enzyme complexes and substances with antioxidant properties, suppresses appetite and increases metabolic energy. Weight gain, changes in body composition, and the risk of chronic diseases are chronic complications of spinal cord injury. The present study investigated the effect of supplementation with alpha-lipoic acid on anthropometric parameters, blood pressure, and dietary intake in men with chronic spinal cord injuries.
Materials and methods: This study was a randomized, double-blind, placebo-controlled clinical trial on 58 men with chronic spinal cord injuries divided into two groups: one group received 600 mg of supplemental alpha-lipoic acid (n = 28) and one received a placebo (n = 30). The duration of intervention was 12 wk. At the beginning and the end of the study, IL-6, hs-CRP, weight, height, waist circumference, and food intakes were measured. Dietary intakes and statistical analysis were done using N4 and SPSS16 software, respectively.
Results: No significant differences were observed in IL-6 and hs-CRP levels between the two groups or in the intervention group. Significant differences were observed in mean systolic and diastolic blood pressure between the two groups and in the intervention group. There were significant differences between the means of the groups and in the intervention group for weight, BMI, waist circumference, energy, carbohydrate, protein and fat intakes between the two groups and in the intervention group. No significant differences were observed for micronutrient intake (vitamins E, C, A, beta-carotene, selenium and zinc).
Conclusion: Alpha-lipoic supplementation decreased anthropometric indices, blood pressure, energy, and micronutrient intake in male patients with chronic spinal cord injuries.
Keywords: Alpha-lipoic acid, Spinal cord injury, Inflammation, Anthropometric indices, Blood pressure, Dietary intake. |
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| Keywords: Alpha-lipoic acid, Spinal cord injury, Inflammation, Anthropometric indices, Blood pressure, Dietary intake |
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Full-Text [PDF 267 kb]
(5435 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/01/26 | Accepted: 2014/01/26 | Published: 2014/01/26
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Mohammadi V, Eghtesadi S, Khalili M, Jazayeri S, Saberi H, Keshtkar Aghababaee S, et al . Effect of alpha-lipoic acid supplementation on anthropometric indices, hypertension, and food intake in male patients with chronic spinal cord injury. Iranian J Nutr Sci Food Technol 2014; 8 (4) :1-12 URL: http://nsft.sbmu.ac.ir/article-1-1492-en.html
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