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Effects of oral resveratrol supplementation on inflammation and quality of life in patients with ulcerative colitis
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M Samsami   , N Ebrahimi Daryani , P Rezanejad , A Hekmatdoost * |
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Abstract: (7708 Views) |
| Background and Objective: Ulcerative colitis (UC) is an inflammatory bowel disease in which immune and inflammatory factors are thought to be a factor. Resveratrol is an antioxidant and anti-inflammatory compound. This study determined the effects of resveratrol compound on inflammatory factors in patients with ulcerative colitis.
Materials and Methods: This study was a double-blind randomized clinical trial conducted on 50 patients with UC. Subjects received one capsule daily for 6 wk of either resveratrol (500 mg) or a placebo. Inflammatory factors, anthropometric measures, and IBDQ-9 scores were assessed at baseline and at the end of the study. STATA12 software was used for data analysis.
Results: No significant differences were found in the background variables between the two groups at baseline. The results indicated that resveratrol supplementation for 6 wk significantly decreased plasma levels of TNF-a and hs-CRP and the activity of NF-κB over the placebo group (p < 0.001). Significant differences remained after adjustment for vitamin C (p < 0.0001). The IBDQ-9 scores increased significantly in the resveratrol group over the placebo group (p < 0.001).
Conclusion: The findings of this study showed that resveratrol supplementation can be useful in patients with ulcerative colitis.
Keywords: IBD, Ulcerative colitis, Resveratrol, Inflammation |
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| Keywords: IBD, Ulcerative colitis, Resveratrol, Inflammation |
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Full-Text [PDF 251 kb]
(3624 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/04/28 | Accepted: 2014/04/28 | Published: 2014/04/28
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