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Does Increasing the Intake of Fruits and Vegetables Affect on Bone Resorption and Formation Markers in Postmenopausal Osteopenic Women?
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S Ebrahimof *   , P Angoorani , M Mehrzadi , V Pishvae , B Larijani , M Kimiagar |
| Students' Research Committee, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran , s.ebrahimof@sbmu.ac.ir |
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Abstract: (8233 Views) |
| Background and Objectives: Osteoporosis and bone fractures are major health problems because of the large health care costs associated with their clinical consequences. Fruits and vegetables and some nutrients abundant in them have been shown to affect bone formation and resorption. In the present study, we evaluated the effects of increasing fruit and vegetable intake on bone resorption and formation in postmenopausal osteopenic women.
Materials and Methods: Overall, 52 postmenopausal women (aged 50-60 years) participated in the present single-blind randomized clinical trial. The subjects were randomly assigned into intervention (daily extra 400 grams fruits and vegetables for 12 weeks) or control (with no dietary change from habitual intake) groups. Fruits and vegetables were delivered to the intervention group weekly and free of charge. Serum osteocalcin and crosslaps were measured at baseline and after 12 weeks of intervention.
Results: Forty–five participants completed the study. Fruit and vegetable intake in the intervention group increased significantly compared to the baseline and also compared to the control group (p<0.0001). Increasing fruit and vegetable intake for 12 weeks reduced serum osteocalcin by 15% and crosslaps by 4%. The reduction was not statistically significant after adjustment for the confounding factors.
Conclusion: Increasing fruit and vegetable intake may not reduce bone turnover in postmenopausal osteopenic women. Longer duration clinical trials are recommended to clarify whether fruit and vegetable intake can benefit bone metabolism and health in postmenopausal osteopenic women.
Keywords: Fruit and vegetables, Osteopenia, Postmenopause, Bone markers |
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| Keywords: Fruit and vegetables, Osteopenia, Postmenopause, Bone markers |
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Full-Text [PDF 235 kb]
(2300 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/05/28 | Accepted: 2015/01/14 | Published: 2015/03/18
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