fa اثر محافظتی تمرین هوازی همراه با مصرف سیر بر لیپوکالین-2 و IL-1ß در زنان چاق مبتلا به فشار خون بالا تغذيه nutrition پژوهشي Research <span style="font-family:b titr;">سابقه و هدف:</span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">چاقی و التهاب نقش مهمی در افزایش فشار خون دارند. هدف از این پژوهش بررسی اثر محافظتی تمرین هوازی همراه با مصرف سیر&nbsp; بر شاخص‌های التهابی (</span></span><span dir="LTR"><span style="font-size:9.0pt;">Lcn-2</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:9.0pt;">IL-1&szlig;</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> ) در زنان مبتلا به فشار خون بالا و چاق می‌باشد.</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"></span></span><br> <span style="font-family:b titr;">مواد و روش</span><span dir="LTR"><span style="font-size:9.0pt;">‌</span></span><span style="font-family:b titr;">ها:</span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">تعداد 36 نفر زن مبتلا به فشارخون از شهر ساری انتخاب و به&shy;طور تصادفی به</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">چهار</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">گروه</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">(کنترل ، سیر، تمرین و تمرین</span></span><span dir="LTR"><span style="font-size:9.0pt;">+</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">سیر)</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">تقسیم</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">شدند. گروه&shy;های</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">تمرین</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">به&shy;مدت</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">هشت</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">هفته،</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">هر</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">هفته</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">سه</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">جلسه</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">(با شدت 55 تا 65&nbsp; درصد</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">ضربان</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">قلب ذخیره و مدت 30 تا 55 دقیقه)</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">در</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">برنامه</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">تمرینی</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">هوازی</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">فزاینده شرکت</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">کردند. گروه&shy;های سیر و تمرین</span></span><span dir="LTR"><span style="font-size:9.0pt;">+</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">سیر، 1000 میلی&shy;گرم مکمل تجاری سیر را به مدت هشت هفته (پس</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">از</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">صبحانه</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">و</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">شام) مصرف نمودند. دو</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">روز</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">قبل</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">و</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">بعد</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">از</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">اجرای پروتکل، در حالت ناشتا</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">خون&shy;گیری</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">انجام</span></span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">شد. برای تجزیه و تحلیل آماری از تحلیل واریانس در سطح معنی‌داری 05/0</span></span><span dir="LTR"><span style="font-size:9.0pt;"> p&le;</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> استفاده شد.</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"></span></span><br> <span style="font-family:b titr;">یافته</span><span dir="LTR"><span style="font-size:9.0pt;">‌</span></span><span style="font-family:b titr;">ها</span><span dir="LTR"><span style="font-size:9.0pt;">‌</span></span><span style="font-family:b titr;">:</span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">نتایج نشان داد که میزان وزن، شاخص توده بدنی و فشار خون سیستولی در گروه‌های تجربی کاهش معنی‌داری داشت (به ترتیب 009/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">، 010/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و 000/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">). همچنین کاهش معنی‌داری در میزان </span></span><span dir="LTR"><span style="font-size:9.0pt;">Lcn-2</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:9.0pt;">IL-1&szlig;</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> در گروه سیر (019/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و 014/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">)، تمرین (000/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و 029/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">) و تمرین+سیر (001/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و 004/0</span></span><span dir="LTR"><span style="font-size:9.0pt;">p=</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;">) مشاهده شد.</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"></span></span><br> <span style="font-family:b titr;">نتیجه گیری:</span> <span style="font-family:b nazanin;"><span style="font-size:11.0pt;">به‌نظر می‌‌رسد تمرینات ورزشی هوازی همراه با مصرف سیر باعث بهبود شاخص‌های التهابی </span></span><span dir="LTR"><span style="font-size:9.0pt;">Lcn-2</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> و </span></span><span dir="LTR"><span style="font-size:9.0pt;">IL-1&beta;</span></span><span style="font-family:b nazanin;"><span style="font-size:11.0pt;"> همراه با کاهش فشار خون سیستولی و ترکیب بدنی در زنان دارای فشار خون بالا و چاق می‌شود.</span></span> <strong>Background and Objectives:</strong> Obesity and inflammation play an important role in the development of hypertension. The aim of this study was to examine the protective effect of aerobic training along with garlic on some inflammatory indices (Lcn-2 and IL-1&beta;) in obese women with high blood pressure.<br> <br> &nbsp;<strong>Materials & Methods:</strong> In this study, 36 women with&nbsp;hypertension were selected from Sari City (north of Iran) and were randomly divided into four groups (Control, Garlic, Training and Training+Garlic). The training groups participated in a progressive aerobic training for eight weeks, three sessions a week (55 to 65% of the reserved heart rate and for 30 to 55 min). The Garlic and Training+Garlic groups were provided with 1000 mg of commercial garlic supplement for eight weeks (after breakfast and dinner). Two days before and after the protocol, the blood&nbsp;samples&nbsp;were&nbsp;taken in fasting state. Statistical analysis was performed using a one way analysis of variance, and significance was accepted at p &le; 0.05.<br> <br> <strong>Results:</strong> The results showed that the weight, body mass index (BMI) and systolic blood pressure decreased significantly in the experimental group ( p=0.009, p=0.010 and p=0.000, respectively)<span dir="RTL">.</span> Also there was a significant reduction of Lcn-2 and IL-1&beta; in the Control-Garlic (p=0.019 and p=0.014), Control-Training (p=0.000 and p=0.029) and Training+Garlic groups (p=0.001 and p=0.004).<br> <br> <strong>Conclusion:</strong> It seems that aerobic training and garlic reduce the inflammatory indices of Lcn-2 and IL-1&beta; with reduced SBP and body composition in women with high blood pressure and obesity.<span dir="RTL"></span> ورزش هوازی, سیر, التهاب و فشار خون Aerobic exercise, Garlic, Inflammation, Blood pressure 25 34 http://nsft.sbmu.ac.ir/browse.php?a_code=A-10-3042-2&slc_lang=fa&sid=1 L khatami saravi سیده لیلا خاتمی ساروی elhamkhatami1357@gmail.com 11500319475328460019519 11500319475328460019519 No Islamic Azad University دانشگاه آزاد اسلامی A abdi احمد عبدی a.abdi58@gmail.com 11500319475328460019520 11500319475328460019520 Yes Islamic Azad University دانشگاه آزاد اسلامی AR barari علیرضا براری alireza54.barari@gmail.com 11500319475328460019521 11500319475328460019521 No Islamic Azad University دانشگاه آزاد اسلامی