Background and Objectives: Muscle damage resulting from exercise is a phenomenon that occurs in all static and dynamic exercises especially in wrestling. Muscle damage leading to problems in muscle structure and releasing intracellular enzymes (Creatine kinase and lactate dehydrogenase) into the bloodstream after activity. So, wrestlers need perfect nutrition. The aim of this study was to investigate the effect of short-term supplementation of two different doses of colostrum powder on cellular damage factors in male wrestlers.
 Materials & Methods: 26 wrestlers of Tabriz university participated with characteristics (with mean and standard deviation age 21/48± 1/9 years, height 174/64± 6 cm, weight 71/ 96± 10/2 kg, fat content 9/78± 3/6  % and BMI 24/35± 2/7 kg / m²) in the form of a semi-experimental double-blind and were divided to three groups, of which nine person were in placebo (control group), nine and eight person consuming colostrum supplementation with 30 and 50 grams per day (experimental groups 1 and 2) respectively. Then, two tests were carried out (Wingate feet (30 seconds) and the simulated wrestling test, two step by three-minute interval of 30 seconds) and also there was 30 minutes rest time between the two tests. After two weeks of supplementation, tests were repeated in accordance with the previous format. Serum Creatine kinase and lactate dehydrogenase were taken in four stages before and after simulated wrestling test and analyzed according to the Eliza method.
Results: Results showed that levels of Creatine kinase and lactate dehydrogenase in two experimental groups decreased subsequently using short term Colostrum powder with two amount of 30 and 50 grams in a day, with wrestling training after Wingate and simulated wrestling tests in comparison to the control group.
Conclusion: With regards to the positive effects of Colostrum on cell damage factors and Colostrum being known as a nutrient and authorized Foodstuff, it is therefore recommended,  especially in wrestling and the use of this supplementation during training and competition cautiously for decreasing cell damages in wrestlers.