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Nowadays, poultry meat is one of the most important sources of animal protein in the world. As the world population continue to increase, so there is an increasing demand for poultry meat. Regarding meat contamination to infectious disease, favorable effects of synbiotic in prevention of poultry infection is reviewed. Related scientific sources were used at present study. Article content were collected using internet and literature review and scientific documents were reviewed since 1989. Poultry industry is threaten by some pathogenic micro organisms such as salmonella, clostridium, campylobacter and Escherichia coli. This infections cause negative growth rate, increasing antibiotic utilization and consequent economic losses. Unfortunately, excessive and long term use of antibiotic for veterinary purposes, especially in poultry industry results in antibiotic resistant. So, some developed countries have restricted the use of antibiotic in poultry diet and many researches are done to introduce alternative compounds. probiotics and prebiotices have beneficial effects in poultry performance and prevention of infectious diseases and could be used in poultry nutrition and infection control. Keywords: Prebiotic, Probiotic, Antibiotic resistance, White meat