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Showing 8 results for Curcumin
Shaghayegh Sheikhzadeh, Mohammad Alizadeh, Mahmoud Rezazad,
Volume 11, Issue 2 (7-2016)
Abstract
Background and Objectives: In addition to the numerous benefits of biopolymeric nanocomplex, it has drawbacks including difficulty in strict control of particle size and to prevent particle agglomeration. In this study, the influence of Tween 20 on the electrostatic interaction between sodium caseinate and gum Arabic was evaluated.
Materials and Methods: Initially, the organic phase (curcumin in ethanol) was introduced to aqueous phase (sodium caseinate, gum Arabic and Tween 20). Then by reducing the pH, the nanoparticles were formed. To evaluate the effects of the independent variables on the responses, the Box-Behnken design was used. The antioxidant activity of samples was evaluated by 1, 1diphenyl 2 picryl hydrazyl radical inhibition assay.
Results: Tween 20 has a significant effect on particle size, and particle size distribution (p<0/0001). Sodium caseinate and Tween 20 have significant effects on the encapsulation efficiency and antioxidant activity of curcumin nanocapsules (p<0/0001). Using desirability function, optimal processing conditions was achieved in the sodium caseinate concentration (0/28%), Arabic gum concentration (0/5469%), Tween 20 concentration (0/18%) and pH (5.02).
Conclusion: Due to the high encapsulation efficiency and antioxidant activity of curcumin nanocomplex and no need for high energy equipment such as homogenizer, this method is suggested as a simple, fast and low-energy technique.
Keywords: Curcumin, Nonionic surfactant, Protein/polysaccharide nanocomplex, Antioxidant activity
Abdolali Banaeifar, Hassan Shahkandi, L Behbodi Tabrizi ,
Volume 11, Issue 4 (1-2017)
Abstract
Background and Objectives: Curcumin as a natural antioxidant is used in some studies. On the other hand, regarding the limited number of studies related to consumption of curcumin in exercise, and according to the role of the liver as the tissue involved in oxidative stress in athletes, in the present study, the effect of 8 weeks of endurance training and curcumin supplementation of antioxidants (superoxide dismutase, glutathione peroxidase and catalase) on the liver of rats was studied.
Materials and Methods: Thirteen male Wistar rats were randomly divided into four groups as control (n=6), training (n=9), curcumin (n=9), and curcumin-training (n=9). The training groups underwent an endurance training program for 8 weeks. The exercise program running on a treadmill with no incline for 5 days per week for 30-70 minutes was conducted. The rats in curcumin and curcumin-training groups received 30 mg per kg of body weight of the injected curcumin solution for 3 days a week. 48 hours after the last training session, samples of tissues were collected for the GPX, CAT and SOD measurements. Data were analyzed using Two-way ANOVA test at α≤0.05.
Results: Eight weeks consumption of curcumin caused a significant increase on the level of superoxide dismutase and glutathione peroxidase enzymes in the curcumin group (p≤0.003). Also there was a significant increase on glutathione peroxidase enzyme in the curcumin-training group (p≤0.001). However, effect of curcumin supplementation along with endurance training on catalase and superoxide dismutase was not significant.
Conclusion: The findings suggest that Curcumin intake along with endurance training can maintain or increase enzymatic antioxidant defense in the liver of rats.
Keywords: Curcumin, Antioxidant, Liver tissue, Training, Male rat
M Mazaheri, Aa Saboury, M Habibi Rezaei, M Farhadi, Aa Moosavi-Movahedi,
Volume 12, Issue 1 (4-2017)
Abstract
Curcumin as the biologic active of turmeric has many biological properties such as anti-inflammatory, anti-oxidant, anti-diabetic and anti-cancer activities. Although poor solubility of curcumin leads to limitation of its medical and biological properties, but many high quality studies show that it has major benefits for digestive and defensive systems of both humans and animals, and displays activities against a variety of diseases. Curcumin’s effective ability of inhibition protein fibrillation and inhibition of ROS production studied by this group confirms these claims. It reacts to more than 30 proteins, and modulates their function by direct or indirect reactions. Extensive research has been done on increasing its activity, solubility and curative effects on human health. But it is imperative that well-designed clinical trials, supported by better formulations of curcumin or novel routes of administration be conducted to improve its bioavailability. In this review, we describe some of the biological and physicochemical properties, the mode of actions, and the therapeutic usages of curcumin.
Keywords: Curcumin, Inflammation, Antioxidant, Anticancer, Antidiabetic agent
F Feizolahi, Ma Azarbayjani, M Nasehi, M Peeri,
Volume 13, Issue 3 (9-2018)
Abstract
Background and Objectives: One of the most common patterns of ethanol consumption is binge drinking, which is associated with long-term behavioral disorders. So the interventions causing to improve health conditions in a short-time can be very important. The purpose of this study was to investigate the effects of curcumin and swimming training after binge ethanol drinking on the mitochondrial biogenesis of the hippocampal tissue in male rats.
Materials and Methods: In an experimental study, Wistar male rats (200-250g) received ethanol/dextrose for four days every eight hours. After six days of avoidance, rats in the ethanol group were randomly divided into four groups: 1) control; 2) swimming training; 3) curcumin; 4) swimming training and curcumin. A dextrose group was also considered as ethanol control in a completely similar period. PGC-1α and TFAM genes expression was measured in the hippocampal tissue.
Results: After 20 days of withdrawal, PGC-1α expression was significantly less than that in the dextrose group. After two weeks, swimming training could but nocurcumin could not significantly increase PGC-1α gene expression comparing to the control group. The combination of curcumin and swimming significantly increased the expression of PGC-1α and TFAM genes in the hippocampus tissue.
Discussion: The results showed that combination of curcumin and swimming training could increase the expression of PGC-1α and TFAM genes, and improved mitochondrial biogenesis in the rats' hippocampus after binge ethanol drinking.
S Dolati, A Hariri Far,
Volume 15, Issue 4 (1-2021)
Abstract
Background and Objectives: Mental health promotion is a useful strategy to achieve developmental indicators. The objective of this study was to investigate effects of curcumin consumption and aerobic training on mental health and body mass index of overweight middle-aged women.
Materials & Methods: In this quasi-experimental study, 40 women in the age group of 30–45 years with body mass index of 24.9–29.9 were divided into four major groups of ten people: including "aerobic training and placebo", "supplement", "aerobic training and supplement" and "placebo". Data were collected using demographic questionnaires, anthropometric indices and general health questionnaires. Aerobic training was carried out three times per week for two months. "Supplement" and "aerobic and supplement" groups received two 250-mg curcumin capsules daily. In the first stage, height and weight were measured and the general health questionnaires were filled. After two months, participants’ weight was measured and the general health questionnaires were completed. Independent t-test, paired t-test, univariate analysis of covariance and Bonferroni post-hoc test were used to analyze data. The level of significance was p < 0.05.
Results: Body mass index significantly decreased in “supplement” (p = 0.015) and “supplement and exercise” (p = 0.028) groups. Decreases in overall mental health scores were significant in “supplement” group only (p = 0.046). All subscales of mental health included significant decreases in all groups. No significant relationships were seen between the exercise and curcumin with the overall mental health scores (p < 0.05). The four groups were significantly different in physical symptoms and depression.
Conclusion: Although curcumin use and aerobic training alone can improve BMI and mental health, curcumin use with aerobic training does not appear to include interactive effects. Therefore, further comprehensive studies with changes in exercise programs and duration of interventions and use of other assessment methods of mental health are recommended.
N Shahgholian, Gh Rajabzadeh,
Volume 17, Issue 2 (7-2022)
Abstract
Background and Objectives: Benefits of the effects of plant compounds with therapeutic characteristics depend on the bioavailability of their active ingredients. Curcumin includes limitations such as low stability and solubility as well as sensitivity to processing conditions and gastrointestinal conditions. Therefore, novel methods such as nanocomplex preparation in these compounds have been developed.
Materials & Methods: To increase solubility and stability of curcumin, a curcumin-albumin nanocomplex was prepared. The response surface methodology-face cantered composite design statistical design was used to optimize three factors in preparation of nanoparticles. Factors included organic phase volume (6.4–11.11% v/v), pH (3–7) and curcumin ratio (5000–000 μg). Glutaraldehyde and tannic acid were used for crosslinking. Particle size, zeta potential (dynamic light scattering method), particle morphology (field emission-scanning electron microscopy, atomic force microscopy) and crosslinking index (ninhydrin and Fourier-transform infrared spectroscopy) were investigated. Factors and responses were analyzed using Design Expert Software v.8.
Results: In curcumin nanocomplex, the optimal conditions for the production of albumin nanoparticles were assessed at pH far from the isoelectric point of albumin and a volume proportion of the organic phase of 11.4%. For simultaneous achievement of the smallest particle with the highest curcumin encapsulation and desirability factor, the optimum efficiency was achieved at 3400 μg of curcumin. Curcumin encapsulation efficiency and particle size was 72.54% and less than 230 nm, respectively. Use of tannic acid increased the efficiency of curcumin entrapment in albumin nanocomplex
(p < 0.05).
Conclusion: Results of this study showed that use of albumin-curcumin nanocomplex along with tannic acid as a crosslinking agent increased encapsulation and stability of curcumin.
S Behjati Hosseini, Aa Moosavi-Movahedi,
Volume 17, Issue 3 (10-2022)
Abstract
Curcumin is an active ingredient in the powdered root of turmeric plants (Curcuma longa) from the ginger family and its yellow color and miraculous preventive and therapeutic characteristics have been used for many years. Identification of the structure of curcumin has always been interested by the scientists due to its low solubility, bioavailability and viability for its further uptake by the target cells. In 2011, the corresponding author of this study and his colleagues used camel milk beta-casein micelles to increase the solubility of curcumin in aqueous solvents by 2,500 times. Nowadays, the article has been cited more than 300 times internationally. These citations are linked to various carriers such as milk proteins and fats, bovine serum albumin, polyphenols, polyesters and polysaccharides, hydrogels, nanogels, nanoparticle self-assembled peptides and various protein transporters to enhance solubility and bioavailability of curcumin. In this study, these citations were reviewed and classified and their achievements were addressed.
F Sharifi, V Dabidi Roshan,
Volume 18, Issue 3 (10-2023)
Abstract
Background and Objectives: Despite the effectiveness of Adriamycin in the treatment of various types of cancer, its cardiovascular complications have become challenging, especially in the elderly. The aim of this study was to investigate the preventive effects of forced and voluntary aerobic exercise and nanocurcumin supplementation on aortic fibrosis following chronic induction of adriamycin in aging rats.
Materials & Methods: Seventy 12-week-old male Wistar rats were randomly divided into 10 experimental and control groups. Aging was induced by digalactose (100 mg/kg). Forced aerobic training groups ran five sessions weekly for six weeks on a treadmill (25-54 minutes/day, slope 0%, speed 15-20 meters/minute). Voluntary exercise groups had access to a running wheel for six weeks. In the last two weeks, 15 days of subcutaneous injection (1 mg/kg/day) of adriamycin/saline and 14 days of nanocurcumin induction (100 mg/kg/day) by gavage were performed. Forty-eight hours after the last session, the rats were sacrificed and the ascending aorta was removed. Mallory's trichrome staining was performed for histological analysis. The thickness of the collagen and elastin area was measured.
Results: There was no significant difference in elastin thickness of aortic tissue between different groups (p=0.197). Collagen thickness significantly due to voluntary-exercise+Adriamycin (p=0.003), forced-exercise+Adriamycin (p<0.001), nanocurcumin+Adriamycin (p<0.001), voluntary-exercise+nanocurcumin+Adriamycin (p<0.001), and forced-exercise+nanocurcumin+Adriamycin (p<0.001) was significantly lower than the Adriamycin group. Also, collagen/elastin thickness ratio due to voluntary-exercise+Adriamycin (p=0.003), forced-exercise+Adriamycin (p=0.001), nanocurcumin+Adriamycin (p=0.002), voluntary-exercise+nanocurcumin+Adriamycin (p=0.015), and forced-exercise+nanocurcumin+Adriamycin (p<0.001) was less than Adriamycin group.
Conclusion: All the approaches used in the present study may be valuable treatments to neutralize the increase in aortic fibrosis caused by Adriamycin, which is partly due to the positive effects of aerobic exercise and also the beneficial effect of nanocurcumin on the cardiovascular system.
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