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Effects of dietary resveratrol supplementation on liver enzymes, hs-CRP, and hepatic steatosis in patients with nonalcoholic fatty liver disease
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F Faghihzadeh   , P Adibi , A Hekmatdoost * |
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Abstract: (16384 Views) |
| Background and Objective: Resveratrol is an antioxidant compound that has been shown to be effective in the management of some diseases. The present study investigated the effects of resveratrol supplementation on serum liver enzymes, inflammatory factors, and the degree of hepatic steatosis in patients with nonalcoholic fatty livers.
Materials and Methods: Fifty patients with NAFLD were randomly assigned to groups that received either resveratrol or a placebo. All patients received 1 capsule (resveratrol or placebo) daily. Both groups were advised to follow an energy-balanced diet and to be physically active. Liver enzymes, inflammatory markers, hepatic steatosis, anthropometric measurements and physical activity were assessed at baseline and at the end of the study. The SPSS 16 and Kolmogorov-Smirnov, paired t-test, t-test and chi-2 were used for data analysis.
Results: No significant differences were observed for the monitored variables between the two groups at baseline. After treatment, the group consuming dietary resveratrol supplementation showed a statistically significant decrease over the control group for ALT and hs-CRP (p < 0.05). Ultrasonography also showed a significant decrease in the level of steatosis in the resveratrol group over the placebo group (p < 0.05).
Conclusion: The positive effects of resveratrol supplementation in improving liver enzyme values and the degree of hepatic steatosis in patients with nonalcoholic fatty liver disease suggest that it can be recommended for such patients.
Keywords: NAFLD, Resveratrol, hs-CRP |
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| Keywords: NAFLD, Resveratrol, hs-CRP |
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Full-Text [PDF 311 kb]
(6056 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/01/27 | Accepted: 2014/01/27 | Published: 2014/01/27
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