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:: Volume 11, Issue 3 (Autumn 2016) ::
Iranian J Nutr Sci Food Technol 2016, 11(3): 21-30 Back to browse issues page
The Effects of 8 Weeks of Vitamin C Intake and Regular Aerobic Exercise on Serum Brain-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels in Obese Girls
M Habibian * , H Khosravi , P Farzanegi
Dept. of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar , habibian_m@yahoo.com
Abstract:   (6775 Views)

Background and Objectives: Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) have a wide range of biological activities that are influenced by childhood obesity. Therefore the purpose of this study was to examine the effects of 8 weeks of vitamin C intake and regular aerobic exercise on serum BDNF and IGF-1 levels in obese girls.

Materials & Methods:  In this quasi-experimental research, 28 obese girls were selected and randomly divided into four equal groups as follows: control, exercise, vitamin C, and combined. Aerobic exercise was carried out at 50% to 70% maximal heart rate and 3 sessions per week for 8 weeks. The vitamin C and combined groups consumed 500mg vitamin C tablets 3 times per week. Fasting blood samples were collected before and 48 hours after the last interventions. Serum BDNF and IGF-1 levels were measured by ELISA and enzyme immunoassay methods, respectively.

Results:  For the vitamin C, exercise and combined intervention groups, the levels of BDNF after 8 weeks were increased and the IGF-1 levels were reduced. Furthermore, all the three interventions were associated with significantly greater percent changes in the BDNF and IGF-1 levels than in the control group, but the effect of combined intervention on IGF-1 percent changes was only greater in comparison to the other interventions (p<0.05).

Conclusion: The favorable effects of the independent and combined interventions of aerobic exercise and vitamin C intake may be partly mediated by the impact of these interventions in regulation of the growth factors‘(BDNF and IGF-1) levels. But the combined intervention could further reduce IGF-1 levels in comparison to other interventions.

Key words: Aerobic exercise, Brain-derived neurotrophic factor, Insulin-like growth factor-1, Vitamin C

 

Keywords: Aerobic exercise, Brain-derived neurotrophic factor, Insulin-like growth factor-1, Vitamin C
Full-Text [PDF 221 kb]   (2621 Downloads)    
Article type: Research | Subject: nutrition
Received: 2016/01/7 | Accepted: 2016/06/13 | Published: 2016/09/18
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Habibian M, Khosravi H, Farzanegi P. The Effects of 8 Weeks of Vitamin C Intake and Regular Aerobic Exercise on Serum Brain-Derived Neurotrophic Factor and Insulin-like Growth Factor-1 Levels in Obese Girls. Iranian J Nutr Sci Food Technol 2016; 11 (3) :21-30
URL: http://nsft.sbmu.ac.ir/article-1-2128-en.html


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Volume 11, Issue 3 (Autumn 2016) Back to browse issues page
Iranian Journal of  Nutrition Sciences and Food  Technology
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