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Vitamin D status as a determining factor for metabolic syndrome: A case-control study
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M Zahedi-Rad   , N Shariatzadeh , TR Neyestani * , Sh Salek-zamani , H Alavi-Majd , A Hoshiar-rad , A Kalayi , A Gharavi , A Doustmohammadian |
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Abstract: (8229 Views) |
| Background and Objective: This study was undertaken to assess vitamin D status in nonmenopausal women with metabolic syndrome (MeS) and to evaluate its possible role in inflammation and other components of MeS.
Materials and Methods: A case-control study was conducted during late fall and winter 2009–10. A total of 375 women with waist circumference (WC) $88 cm were examined to find 100 who met MeS criteria according to the National Cholesterol Education Program (NCEP)/Adult Treatment Panel (ATP) III criteria (NCEP/ATP III). Of those without MeS, 100 age- and residence area-matched women were selected as a control group. Anthropometric and laboratory evaluations were performed. Waist-to-hip ratio (WHR), body mass index (BMI), homeostatic model of insulin resistance (HOMA-IR) and body fat mass (FM) were also evaluated.
Results: Women with MeS had significantly higher BMI, waist circumference (WC) and FM but lower serum osteocalcin than controls. There was no significant difference in serum 25 hydroxyvitamin D (25[OH]D), intact parathyroid hormone (iPTH) or vitamin D status between the two groups. Serum highly sensitive C-reactive protein (hsCRP) concentration was significantly higher in the MeS group, compared to the controls (3.4 ± 3.3 vs 2.0 ± 1.9 mg/L, P , 0.001). The difference remained significant even after controlling for BMI (P = 0.011), WC (P = 0.014) and FM (P = 0.005). When comparison was made only in those subjects with insulin resistance (HOMA-IR . 2.4), hsCRP was still higher in the MeS group (n = 79) than in the control group (n = 61) (P , 0.001). When data were categorized according to vitamin D status, in the MeS group significantly higher plasma glucose concentrations were observed in subjects with vitamin D deficiency compared to those with insufficiency or sufficiency (104.0 ± 11.7, 83.0 ± 11.3 and 83.2 ± 9.9 mg/dL, respectively, P , 0.001). Interestingly, their WC or WHR did not show any significant difference. In stepwise regression analysis, 25(OH)D was the main predictor of both hsCRP and plasma glucose.
Conclusion: Vitamin D status may, at least in part, be a determining factor of systemic inflammation and the related metabolic derangements of MeS.
Keywords: Metabolic syndrome, Vitamin D, Inflammation |
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| Keywords: Metabolic syndrome, Vitamin D, Inflammation |
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Full-Text [PDF 241 kb]
(2076 Downloads)
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Article type: Research |
Subject:
Food Science
Received: 2013/03/4 | Accepted: 2013/11/19 | Published: 2013/11/19
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