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Effects of regular aerobic training accompanied by omega-3 supplementation on soluble intercellular adhesion molecule-1 and lipid profiles of obese elderly women
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A Tofighi   , G Ghafari * |
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Abstract: (8961 Views) |
| Background and Objective: Cardiovascular disease is usually diagnosed by measuring lipid profiles however, it is also observed in people with normal lipid profiles. This study examined more sensitive inflammatory markers, such as the soluble intercellular adhesion molecule-1 (sICAM-1) and investigated the effect of 8 wk of regular aerobic training accompanied by omega-3 supplementation on sICAM-1 and lipid profiles of obese elderly women.
Materials and Methods: In a double-blind study, 40 obese women (BMI ≥30) 55 to 65 years of age were selected and randomly divided into 4 groups of 10 subjects: exercise-supplementation, exercise-placebo, supplementation, and control. The exercise program comprised aerobic exercise to 45% to 55% maximum heart rate for 8 weeks each session was sustained for 40 min and continued for 3 sessions per week. Subjects in the supplementation group consumed 2080 mg omega-3 daily and the placebo group consumed a 0.02 dextrose solution as a placebo. Fasting blood samples were collected before and 48 h after the training period.
Results: Interaction effects for exercise and supplementation had a co-increment impact on the significant reduction in sICAM-1 and TG concentration and increased HDL-C for all groups. The effect of exercise, regardless of supplementation, on the reduction of LDL-C was significant and the interaction between exercise and supplementation was significant in reducing the indices (p < 0.05). Only the effect of exercise was significant for cholesterol reduction.
Conclusions: Regular aerobic exercise and omega-3 supplements are effective and moderating factors for reducing sICAM-1 and blood lipids and improving the health of elderly women.
Keywords: sICAM-1, Cardiovascular disease, Omega-3 fatty acid, Elderly women |
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| Keywords: sICAM-1, Cardiovascular disease, Omega-3 fatty acid, Elderly women |
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Full-Text [PDF 244 kb]
(3089 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2013/11/19 | Accepted: 2013/11/20 | Published: 2013/11/20
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