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Efficacy of daily consumption of vitamin D or vitamin D-calcium-fortified doogh on serum concentrations of apoproteins A1, B, and lipoprotein (a) in type 2 diabetic subjects
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TR Neyestani *   , B Nikooyeh , S Heravifard , H Alavi-Majd , A Hoshiar-rad , M Zahedi-Rad , N Shariatzadeh , A Kalayi |
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Abstract: (10139 Views) |
| Background and objective: Cardiovascular disease (CVD) is a major long-term complication and cause of death in patients with type 2 diabetes (T2D). The link between low vitamin D with poor glycemic control, atherogenic lipid profile, and CVD has been documented in some observational studies. Possible links between circulating 25-hydroxycholecalciferol and apoproteins (Apo A1 and B) and atherogenic lipoprotein (a) (Lp(a)) have not been studied to date.
Materials and methods: Ninety subjects with T2D aged 30–60 yr of both sexes were randomly assigned to one of the 3 experimental groups. Each group consumed 2 bottles per of (1) plain doogh (150 mg calcium and no detectable vitamin D per 250 ml) (2) vitamin D-fortified doogh (150 mg calcium and 500 IU vitamin D per 250 ml) or (3) calcium and vitamin D-fortified doogh (250 mg calcium and 500 IU vitamin D per 250 ml) for 12 wk. Anthropometric, dietary, and laboratory assessments, including Apo A1, Apo B, and Lp(a), were recorded.
Results: The increase in vitamin D in groups 2 and 3 groups over group 1 resulted in a significant increase in Apo A1 (mean changes 0.22 ± 0.38, 0.20 ± 0.27, 0.01 ± 0.35 g/l, respectively, p = 0.047) and a significant decrease in serum Lp(a) (mean changes -0.08 ± 0.30, -0.08 ± 0.31, and 0.14 ± 0.25 μmol/l, respectively, p = 0.011). There was no significant difference between groups 2 and 3. Serum Apo B did not change significantly in any group.
Conclusion: Significant amelioration of serum Apo A1 and Lp(a) following improvement of vitamin D levels in T2D subjects may prevent long-term diabetic complications, notably CVD.
Keywords: Vitamin D, Diabetes type 2, Apoproteins, Lipoprotein (a) |
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| Keywords: Vitamin D, Diabetes type 2, Apoproteins, Lipoprotein (a) |
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Full-Text [PDF 168 kb]
(3987 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2013/12/24 | Accepted: 2013/12/24 | Published: 2013/12/24
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