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Association between lipoprotein lipase gene PvuII polymorphism and lipid profile and body mass index in the Turkmen population of Golestan province
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S Eshghinia   , M Moradi * , S Mirzaie , M Davaji , M Agha abbasi , P Asadi , N Ahmadi |
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Abstract: (8554 Views) |
| Background and Objective: Lipoprotein lipase (LPL) is an enzyme that plays a key role in lipid metabolism. Most polymorphisms that have been investigated on the lipoprotein lipase gene include PvuII and HindIII sites. This study examined lipoprotein lipase gene PvuII site polymorphism and its relationship with lipid profiles and body mass indices in the Turkmen population of Golestan province.
Materials and Methods: This study included 295 healthy volunteers from the Turkmen population who were referred to health center laboratories for routine blood testing before marriage in the cities of Gonbad and Kalaleh in Golestan province. The genotypes for lipoprotein lipase gene PvuII polymorphism were determined by PCR-RFLP analysis. The serum lipid profile was measured using an enzymatic method.
Results: The frequencies of the P+P- and P-P- and P+P+ genotypes of the lipoprotein lipase gene PvuII site were, respectively, 49.2%, 32.2%, and 18.6%. No significant effects were found for lipoprotein lipase gene PvuII polymorphism by lipid profile and gender. The P-P- variant was associated with higher levels of LDL, triglycerides, and total cholesterol than for the P+P+ and P+P- genotypes, but they were not statistically significant.
Conclusion: In The Turkmen population of Golestan province, P-P- genotype frequency was greater than for the P+P+ genotype. The results for other populations showed that the frequency of P+P+ genotype was greater than for the P-P- genotype. There is no significant relationship between PvuII genotypes and lipid profiles and BMI in the Turkmen population.
Keywords: Lipid profile, Body mass index, LPL, Polymorphism |
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| Keywords: Lipid profile, Body mass index, LPL, Polymorphism |
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Full-Text [PDF 260 kb]
(2385 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/01/26 | Accepted: 2014/01/26 | Published: 2014/01/26
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