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Effect of probiotics on metabolic profile, hs-CRP and oxidative stress in type 2 diabetic adults
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A Shiranian   , A Salehi-Abargoue , Z Asemi , Z Zare , H Shakeri , S Sabihi , MR Khoshfetrat , A Esmaillzadeh * |
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Abstract: (9604 Views) |
| Background and Objective: No studies thus far have addressed the effects of daily consumption of multispecies probiotic supplements on the metabolic profiles, hs-CRP and oxidative stress of diabetic patients. The present study was designed to determine the effects of multispecies probiotic supplements on metabolic profiles, hs-CRP and oxidative stress in diabetic patients.
Materials and Methods: Fifty-four diabetic patients 35-37 years of age participated in this randomized double-blind controlled clinical trial. The subjects were randomly assigned to consume either a multispecies probiotic supplement (n = 27) or a placebo group (n = 27) for 8 wk. The supplement contained 7 viable and freeze-dried strains of lactobacillus acidophilus (2 × 109 CFU), lactobacillus casei (7×109 CFU), lactobacillus rhamnosus (1.5 × 109 CFU), lactobacillus bulgaricus (2 × 108 CFU), Bifidobacterium breve (2 × 1010 CFU), Bifidobacterium longum (7 × 109 CFU), Streptococcus thermophilus (1.5 × 109 CFU) and 100 mg fructo-oligosaccharide in lactose as a carrier substance. Fasting blood samples were taken at baseline and after 8 wk of intervention to measure metabolic profiles, hs-CRP and biomarkers of oxidative stress.
Results: The consumption of probiotic supplements prevented a rise in the FPG (changes from baseline: +1.54 ± 30.73 vs. +28.73 ± 43.44 mg/dL, p = 0.01) and HOMA-IR (+0.78 ± 1.61 vs. +2.38 ± 3.34, p = 0.03) values. No significant effect was found from the probiotic supplements for serum lipid profiles and HbA1C levels. A significant decrease in serum hs-CRP levels (-777.57 vs. 878.72 ng/ml, p = 0.02) was found after probiotic supplementation compared to the placebo group. Supplementation also significantly increased plasma GSH levels (240.63 vs. -33.46 µmol/L, p = 0.03) compared to the placebo. No significant effect for probiotics was observed for plasma TAC and serum uric acid levels between the two groups.
Conclusion: Multispecies probiotic supplementation for 8 wk by diabetic patients increased glycemic control, decreased serum hs-CRP and increased plasma total GSH. It did not affect serum lipid profiles or total antioxidant capacity.
Keywords: Probiotics, metabolic profiles, hs-CRP, oxidative stress, type 2 diabetics |
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| Keywords: Probiotics, metabolic profiles, hs-CRP, oxidative stress, type 2 diabetics |
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Full-Text [PDF 234 kb]
(2810 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/02/18 | Accepted: 2014/02/18 | Published: 2014/02/18
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