[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
this is a test
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
All Issues
Current Issue
Browse by Authors
Browse by Keywords
For Authors::
Instruction to authors
Subscription::
Registration Information
Subscription Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
Webmail::
Ethical Consideration::
Publication ethics and malpractice statement
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 10, Issue 1 (Spring 2015) ::
Iranian J Nutr Sci Food Technol 2015, 10(1): 1-8 Back to browse issues page
Effect of Cellular Senescence on Insulin Resistance in Diet-induced Obese Wistar Rats
M Cheraghpour , R Shahbazi , R Homayounfar , H Imani , H Zand *
, National Nutrition & Food Technology Research Institute , hamidzand@gmail.com
Abstract:   (8466 Views)
Background and Objectives: Cellular senescence has been known as a tumor suppressor mechanism however, some evidence shows that cellular senescence is an inducer factor for metabolic disorders, such as insulin resistance and diabetes. In this study, the effect of senescence was assayed in the peripheral tissues of diet-induced obese rats. Materials and Methods: 30 male 5-week old wistar rats were randomly assigned into high-calorie diet through 416 kcal/100 g (researcher made) or control diet for 12 weeks. Weight changes, lipid profile, glucose, insulin levels and QUICKI (Quantitative Insulin Sensitivity Check Index) index were measured at the end of the 12th week. Also the tissue samples were isolated, and immune-blotting was performed to identify proteins P16INK4a and P53 (cell senescence markers). Results: P53 levels in the fat tissue and other peripheral tissues of obese rats were significantly higher compared to the control group. P16INK4a expression was increased only in fat tissue but protein was not expressed in other tissues. In the obese rats, the serum levels of glucose (183/60±34/90 vs. 152/40±15/48 P=0.019), cholesterol (60/70±6/88 vs.46/60±7/82 P0.001) and triglyceride (124/60±46/43 vs. 57/20±24/02 P0.001) were more than in the control group but The QUICKI index was significantly lower in the obese rats compared to the control group (p=0.01). Conclusion: Our results suggest that cell senescence in fat tissue can be predisposed to the development of insulin resistance and age-related diseases by generating some alternation in the fat tissue. Keywords: Cellular senescence, Diet-induced obesity, Insulin resistance alternation in fat tissue

Keywords: Cellular senescence, Diet-induced obesity, Insulin resistance
Full-Text [PDF 325 kb]   (2783 Downloads)    
Article type: Research | Subject: nutrition
Received: 2014/04/20 | Accepted: 2014/12/27 | Published: 2015/03/18
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Cheraghpour M, Shahbazi R, Homayounfar R, Imani H, Zand H. Effect of Cellular Senescence on Insulin Resistance in Diet-induced Obese Wistar Rats. Iranian J Nutr Sci Food Technol 2015; 10 (1) :1-8
URL: http://nsft.sbmu.ac.ir/article-1-1589-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 1 (Spring 2015) Back to browse issues page
Iranian Journal of Nutrition Sciences and Food Technology
Persian site map - English site map - Created in 0.04 seconds with 35 queries by YEKTAWEB 4692