Background and Objectives: The results of some studies suggest that garlic and its products at baseline prevent oxidative stress due the incidence of adverse oxidative changes in patients with cardiovascular diseases (CVDs). This study aimed to determine the effect of short-term supplementation of garlic extract on total serum creatine kinase followed by an exhaustive activity in active and inactive girls were doing.

Materials and Methods: The total of 24 female participants were randomly selected (12 active and 12 inactive). Mean age, height, weight, and maximal oxygen consumption of subjects in the active and inactive groups were (22.1±0.63 years, 162±0.05cm, 54.25±7.95kg, and 39.94±8.97ml/kg/min) and (21.8±.98years165±.06cm, 55.73±5.65kg, and 32.42±5.18ml/kg/min), respectively. Both groups completed 14 days of garlic extract supplementation/intake (800 mg per day). Then all the subjects were included in the contract during exhaustive exercise. Initial blood samples were taken at baseline before the start of supplementation; a second blood sample was taken after completion of supplementation; and the third sample was taken after exhaustive activity. Normal data were analyzed with SPSS software (ver. 19) using repeated ANOVA test, Bonferroni test, and t-test at significance level of 5% .

Results: It was revealed that the 14-day consumption of garlic extract on the basis of the study had no significant effect. This extract also failed to increase the damage of creatine kinase after exhaustive activities in the active and passive girls (P<0.05). However, there was a significant difference in increase of enzyme level after exhaustive activity between the active and inactive groups (P<0.05).

Conclusion: The results indicated that creatine kinase levels after exhaustive activity were significantly lower in the active group than in the inactive group; garlic extract plus exercise is recommended.

Keywords: Garlic supplements, Creatine kinas, Active girls, Inactive girls