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The effect of red-seed grapes on the serum lipid levels of hypercholesterolemic subjects
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SH Fattahi *   , M Shakoori , A Aminpour , B Golestan , A Shafighi |
| , fattahishideh@yahoo.com |
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Abstract: (14814 Views) |
| Background and Objectives: The objective was to study the effect of red-seed grapes on the serum levels of total cholesterol (TC) and low-density-lipoprotein-cholesterol (LDL-C) in hypercholester- olemic subjects.
Materials and Methods: In a clinical trial 43 hypercholesterolemic subjects (cholesterol>200mg/dl) were randomly divided into two groups of red-seed grapes (RG) and control (CG). The RG group included 22 subjects (18 female, 4 male) with a mean age of 50 years, taking 500gr red-seed grapes per day for 4 weeks, while the 21 control subjects (17 female, 4 male) with a mean age of 52 years received no treatment. At the beginning of the study, physical activity and BMI were determined. Serum lipid levels (TC, LDL-C, HDL-C and TG) were measured at the beginning and at the end of the period. Dietary intake was also determined before and after the period, in both cases for 3 conseutive days, using the 24-hr recall questionnaire. The fiber and flavonoid contents of the grapes were also determined.The data were analyzed (paired t-test), using SPSS 11.5.
Results: The experimental and control groups were matched with regard to age, sex, BMI, and physical activity. As compared to the CG the mean level of TC in the RG significantly decreased after the 4 week-period (-24.2±6.3 mg/dl in the RG vs 2.8±6.1 mg/dl in the CG, p<0.05). The grapes also, caused a significant decrease in LDL-C in the RG, compared to the control group (-24.3±6.0 mg/dl in the RG vs 4.1±7.5 mg/dl in the CG, p<0.01). There were also reductions in the ratios and in RG compared with those in CG (p<0.05) however, the differences between the 2 groups with regard to HDL-C and TG were not statistically significant.
Conclusion: Red-seed grapes might have beneficial effects on the serum total and low-density-lipoprotein-cholesterol in hypercholesterolemic subjects. Further studies are needed to determine tth effects of these grapes on HDL-C and TG. |
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| Keywords: Hypercholesterolemia, Red-grape seed, Fiber, Flavonoid |
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Full-Text [PDF 155 kb]
(2676 Downloads)
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Article type: Research |
Subject:
Food Science
Received: 2008/06/30 | Published: 2007/03/15
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