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Therapeutic effects of isolated soy protein in rats with acute liver failure
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M Ershad-Langroodi   , MH Eftekhari * , MR Panjeshahin , A Oryan , HR Tabatabaee |
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Abstract: (13834 Views) |
| Background and Objectives: Proteins, as antioxidant compounds, can protect cells against free radical-induced damages. This study was conducted to investigate the protective and antioxidant effects of soy protein isolate (SPI) in acute liver failure in rats.
Materials and Methods: In this experimental study, 48 rats were randomly divided into 3 groups. Groups 1 and 2 were put on a 20 % casein- and group 3 on a 20 % SPI-diet. Liver injuries were induced by injection of dimethylnitrosamine (DMN) (30mg/ml per kg, ip) in groups 2 and 3. Biochemical parameters [serum aspartate amino-transferase (AST), alanine amino-transferase (ALT), alkaline phosphatase (ALP), total protein, albumin, total bilirubin, and malondialdehyde (MDA)], as well as histopathological changes in liver tissue, were assessed at the end of the study.
Results: Dietary SPI resulted in decrease in ALT (270.2±493.6 IU.L-1) (P<0.05) and increase in serum albumin (4.3±0.7 g.dl -1) and MDA (8.5±1.7 nmol.ml-1) levels (P<0.05). SPI did not have significant effect on other factors. Histopathological findings indicated that SPI led to improvement of the damage and rapid hepatocyte regeneration.
Conclusion: Results of our study suggest that an SPI diet can improve acute liver damage and reduce DMN-induced complications. |
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| Keywords: Acute liver failure, Soy protein isolate, Casein |
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Full-Text [PDF 292 kb]
(3121 Downloads)
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Article type: Research |
Subject:
Food Science
Received: 2009/12/15 | Published: 2009/12/15
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