[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 13, Issue 1 (Spring 2018) ::
2018, 13(1): 1-10 Back to browse issues page
Effect of Genistein Supplementation on Insulin Sensitivity, Insulin Resistance, and Beta Cells function Index in Patients with Non-alcoholic Fatty Liver Disease: a Randomized, Controlled Trial
S Amanat , MH Eftekhari * , K Bagheri Lankarani , M Fararouei
Professor Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (539 Views)

Background and Objective: Excess fat accumulation in the liver can be seen in non-alcoholic fatty liver disease (NAFLD). This condition is closely associated with insulin resistance and abdominal obesity. Genistein, one of the major isoflavones, can improve glucose and fat metabolism. The aim of this study was to assess the effect of genistein supplementation on insulin sensitivity, insulin resistance and beta cell function index in NAFLD patients.
Materials and methods: a randomized double-blind clinical trial was done by recruiting ninety-two NAFLD patients for 8 weeks. Participants were assigned to either genistein group, which received daily 250 mg of genistein, or placebo group. All participants received nutritional and physical activity consultation. Anthropometric factors, liver enzymes, fasting blood sugar and insulin were measured. Finally, insulin resistance, insulin sensitivity, and beta cell function were calculated.
Results: Genistein reduced fasting insulin, insulin resistance and insulin sensitivity in comparison with the placebo group. In addition, waist-hip ratio was reduced in the genistein group while no significant changes were observed in BMI, fasting glucose, beta cell function and liver enzymes in genistein groups.
Discussion: this study showed that 8 weeks supplementation with daily 250 mg of Genisetein in NAFLD patients, improved insulin resistance, insulin sensitivity, and waist-hip ratio and it can be considered as an effective supplement for these patients in terms of weight management.
Keywords: Non-alcoholic fatty liver, Genistein, Insulin resistance, Insulin sensitivity

Keywords: Non-alcoholic fatty liver, Genistein, Insulin resistance, Insulin sensitivity
Full-Text [PDF 222 kb]   (175 Downloads)    
Type of Study: Research | Subject: nutrition
Received: 2017/02/20 | Accepted: 2017/09/6 | Published: 2018/04/21
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

amanat S, Eftekhari M, Bagheri Lankarani K, Fararouei M. Effect of Genistein Supplementation on Insulin Sensitivity, Insulin Resistance, and Beta Cells function Index in Patients with Non-alcoholic Fatty Liver Disease: a Randomized, Controlled Trial. Iranian Journal of Nutrition Sciences & Food Technology. 2018; 13 (1) :1-10
URL: http://nsft.sbmu.ac.ir/article-1-2402-en.html


Volume 13, Issue 1 (Spring 2018) Back to browse issues page
Iranian Journal of  Nutrition Sciences & Food  Technology
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3742