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:: Volume 14, Issue 3 (Autumn 2019) ::
2019, 14(3): 11-20 Back to browse issues page
Effects of Coenzyme Q10 Supplementation on Antioxidant Enzyme and Lipid peroxide Activities in Women with Multiple Sclerosis: a Randomized, Placebo-controlled Trial
S Ebrahimi , A.H Haghighi , K Nikkhah, H Hamidi
Abstract:   (534 Views)
Background and Objectives:Oxidative stress has been reported to provide neurodegeneration in multiple sclerosis (MS). Coenzyme Q10 is an endogenous lipid-soluble antioxidant. Up-to-date, no intervention studies have investigated coenzyme Q10 supplementation in MS. The purpose of this study was to investigate oxidative stress and antioxidant enzyme and lipid peroxide activities in women with MS following administration of coenzyme Q10 (300 mg/day).
Materials & Methods:This study was designed as a single-blinded, randomized, parallel placebo-controlled study. Women with MS (n=30) were randomly assigned to placebo (n=15) or coenzyme Q10 (300 mg/day) (n=15) group. The intervention was completed within eight weeks. Plasma coenzyme Q10, oxidative stress (MDA) and antioxidant enzymes activity (SOD, GPX, TAC) were assessed. Data were analyzed using two independent-samples tests (Mann-Whitney U) (P<0.05).
Results:The antioxidant enzyme activity (SOD) (P = 0.001) and coenzyme Q10 (P = 0.002) significantly increased. However, no significant differences were reported for serum levels of MDA, GPX and TAC between the two groups (P > 0.05) after eight weeks of coenzyme Q10 supplementation.
Conclusion:In conclusion, this study has demonstrated that a dose of 300 mg/d of coenzyme Q10 can improve antioxidant enzyme system with no effects on peroxidation lipid (MDA) and DESS in women with MS.
Keywords: Coenzyme Q10, Multiple sclerosis, MS, Lipid peroxidation, Superoxide dismutase
Full-Text [PDF 498 kb]   (304 Downloads)    
Type of Study: Research | Subject: nutrition
Received: 2019/01/19 | Accepted: 2019/04/24 | Published: 2019/10/7
1. V. Chiurchi'u, "Novel targets in multiple sclerosis: to oxidative stress and beyond," Current Topics in Medicinal Chemistry, vol. 14, no. 22, pp. 2590-2599, 2014. [DOI:10.2174/1568026614666141203143801]
2. Adamczyk B, Adamczyk-Sowa M. New insights into the role of oxidative stress mechanisms in the pathophysiology and treatment of multiple sclerosis. Oxidative medicine and cellular longevity,2016. [DOI:10.1155/2016/1973834]
3. Kordi MR, Anooshe, Khodadade, Maghsodi, sanglachi, Hemmatinafar. Comparing the effect of three methods of combined training on serum levels of ghrelin, pro and anti-inflammatory cytokines in multiple sclerosis (MS) patients. zums.ac.ir,2014;22( 91):39-51
4. Moazzami M, Fathi M, Soltani M, Gelardi N. The effects of aerobic exercise in water on cortisol levels and TGF-β in patients with multiple sclerosis. sum.ac.ir, 2014;21(2):207-216
5. Souza-Teixeira F D, Costilla S, Ayán C, García-López D, González-Gallego J, Paz J A D. Effects of resistance training in multiple sclerosis. International Journal of Sports Medicine 2009; 30: 245-250. [DOI:10.1055/s-0028-1105944]
6. Dendrou C A, Fugger L, Friese M A. Immuno pathology of multiple sclerosis. Nature Reviews Immunology 2015; 15: 545-558. [DOI:10.1038/nri3871]
7. Soleimani M, Jameie S B, Barati M, Mehdizadeh M, Kerdari M. Effects of coenzyme Q10 on the ratio of TH1/TH2 in experimental autoimmune encephalomyelitis model of multiple sclerosis in C57BL/6. Ibj.pasteur.ac.ir. 2014; 18(4): 203-211
8. Saravi, S.S.S., Dehpour, A.R.. Potential role of organ chlorine pesticides in the pathogenesis of neurodevelopmental, neurodegenerative, and neurobehavioral disorders: A review. Life Sci 2016; 145, 255-264. [DOI:10.1016/j.lfs.2015.11.006]
9. Almasi S, Rezvanjoo B, Shirazi-beheshtiha S.H, Namvaran-Abbas-Abad A, khosravi M. Protective effect of coenzyme Q10 and vitamin C on cysteamine induced lipid peroxidation. Journal of Veterinary Clinical Research 2014; 5(1)21-29
10. JahaniGh.R, Firoozrai M, MatinHomaee H, Tarverdizadeh B, Azarbayjani M.A, MovaseghiGh.R, et al. The effect of continuous and regular exercise on erythrocyte ant oxidative enzymes activity and stress oxidative in young soccer players. iums.ac.ir, 2010; 17(74): 23-32
11. Hejaze E, Amaani R, Sharafodinzadeh N. Dietary intake of antioxidant status (TAS) in MS patients with that of normal subject. Yafte.lums.ac.ir. 2007;9(3):57-64
12. Sanoobar M, Eghtesadi SH, Azimi A, Khalili M, Khodadadi B, Jazayeri SH, et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Nutritional Neuroscience 2013;123(11): 776-782 [DOI:10.3109/00207454.2013.801844]
13. MillerM, Mrowicka M, Malinowska K, Mrowicki J. The effects of whole-body cryo therapy on oxidative stress in multiple sclerosis patients. Journal of Thermal Biology 2010;57:168-
14. LaFlamme, B. NF-[kappa][beta] signaling disrupted in neurodevelopmental disorders. Nature Genet. 2014; 46(9), 933-933. [DOI:10.1038/ng.3084]
15. Afzalpour M, Gharakhanlou R, Gaeini A, Mohebbi H, Hedayati M, Khazaei M. The effects of aerobic exercises on the serum oxidized LDL and total antioxidant capacity in non-active men. CVD prevention and control. 2008; 3(2):77-82. [DOI:10.1016/j.cvdpc.2008.01.002]
16. Hininger-Favier I, Osman M, Roussel AM., et al. Positive effects of an oral supplementation by Glisodin, a gliadin -combined SOD-rich melon extract, in an animal model of dietary-induced oxidative stress. Phytothérapie, 2016;14(1), 29-34. [DOI:10.1007/s10298-015-0928-4]
17. Cornelius N, Wardman J.H, Hargreaves IP, et al. Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters. Mitochondrion, 2017; 34, 103-114. [DOI:10.1016/j.mito.2017.03.001]
18. Moccia M, Capacchione A, Lanzillo R, Carbone F, Micillo T, Perna F, et al. Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis. Therapeutic advances in neurological disorders, 2019. [DOI:10.1177/1756286418819074]
19. Spindler M, Flint Beal M and Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatr Dis Treat 2009; 5:597-610. [DOI:10.2147/NDT.S5212]
20. . Belousova M, Tokareva OG, Gorodetskaya E, et al. Intravenous treatment with coenzyme Q10 improves neurological outcome and reduces infarct volume after transient focal brain ischemia in rats. J Cardiovasc Pharmacol 2016; 67: 103-109. [DOI:10.1097/FJC.0000000000000320]
21. Gironi M, Borgiani B, Mariani E, Cursano C. Oxidative Stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment. Journal of Immunology Research 2014;26; 2014 [DOI:10.1155/2014/961863]
22. . Choi I, Lee P, Adany P, et al. In vivo evidence of oxidative stress in brains of patients with progressive multiple sclerosis. Mult Scler 2018; 24: 1029-1038. [DOI:10.1177/1352458517711568]
23. Hathcock J.N, Andrew Shao A. Risk assessment for coenzyme Q10 (Ubiquinone).Regulatory Toxicology and Pharmacology. 2006;45.282-288 [DOI:10.1016/j.yrtph.2006.05.006]
24. OmranWaheed M, Al- Tukmagi H, Kadhim Kareem A. Evaluate the effect of coenzymeq10 supplementation on reducing oxidative stress in patients with relapsing remitting Multiple Sclerosis. International Journal of Science and Research 2014;4(11):2262-2264 [DOI:10.21275/v4i11.NOV151622]
25. Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, Littarru G. Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertility and sterility. 2004; 1; 81(1):93-8. [DOI:10.1016/j.fertnstert.2003.05.009]
26. Watts, G.F, Playford, D.A, Croft, K.D, Ward, N.C, Mori, T.A, Burke,V. Coenzyme Q (10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus. Diabetologia.2002; 45: 420-426. [DOI:10.1007/s00125-001-0760-y]
27. Hodgson, J.M, Watts, G.F, Playford, D.A, Burke, V, Croft, K.D. Coenzyme Q10 improves blood pressure and glycemic control: a controlled Trial in subjects with type 2 diabetes. Eur. J. Clin. Nutr.2002; 56: 1137-1142 [DOI:10.1038/sj.ejcn.1601464]
28. Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad M. Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Psychiatry research. 2018 Jul 1; 265:62-9. [DOI:10.1016/j.psychres.2018.03.061]
29. Liu HT, Huang YC, Cheng SB, Huang YT, Lin PT. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutrition journal. 2015; 15(1):85. [DOI:10.1186/s12937-016-0205-6]
30. Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, Nazeri Kakhki SA, Akhondi MM, Sadeghi MR. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double‐blind randomized clinical trial. Andrologia. 2014; 46(2):177-83.-. [DOI:10.1111/and.12062]
31. Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences. 2009; 106(21):8665-70. [DOI:10.1073/pnas.0903485106]
32. Nakhostin-Roohi B. Exercise- induced Oxidative Stress- Is Antioxidants Supplementation Useful? asp.journals.umz.ac.ir. 2016;12(24):129-140
33. Parandak K, Arazi H, Khoshkhahesh F, Nakhostin-Roohi B. The effect of two-week Lcarnitine supplementation on exercise-induced oxidative stress and muscle damage. Asian sports medicine. 2014; 5(2):123.
34. Javanamani R, Nakhostin-Roohi B. The Effect of One-week Glutamine Supplementation on Oxidative Stress Indices in Healthy Young Men. aums.ac.ir, 2015; 15(1):83-9. [DOI:10.12720/joaat.2.1.8-12]
35. Bohlooli S, Barmaki S, Khoshkhahesh F, Nakhostin-Roohi B. The effect of spinach supplementation on exercise-induced oxidative stress. The Journal of sports medicine and physical fitness. 2015; 55(6):609-14.
36. Zimmermann MB. Vitamin and mineral supplementation and exercise performance. Schweiz Z Med Traumatol. 2003; 51(1):53-7.
37. Teixeira VH, Valente HF, Casal SI, Marques AF, Moreira PA. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. Med Sci Sports Exerc.2009; 41(9):1752-60. [DOI:10.1249/MSS.0b013e31819fe8e3]
38. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov 1;33(11):1444 [DOI:10.1212/WNL.33.11.1444]
39. Haghighi A,Heshmati Kia A,Hosseini A. The Effect of Caffeine And Ephedrine Supplement And Their Combination on Maximal Strength And Muscular Endurance in Male bodybuilders. Journal of sport Bioscienes; 2013;5(4):89-107
40. Gϋl I, Gökbel H, Belvİranli M, Okudan N, Bϋyϋkbas S, Basarali K. Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10: J Sport Med Phys Fitness. 2011; 51: 305-312
41. Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, etal. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals: Journal of the International Society of Sports Nutrition. 2008; 5(8). [DOI:10.1186/1550-2783-5-8]
42. Miyamae T, Seki M, Naga T,Uchinosh, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M,Imagawa T, Natsumeda Y, Yokota Sh, Yamamoto Y. Increased oxidative stress and coenzymeQ10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia andfatigue by ubiquinol-10 supplementation: Redox Report. 2013;18 (1):12-19 [DOI:10.1179/1351000212Y.0000000036]
43. Kaikkonen J, Kosonen L, Nyyssonen K, Porkkala-Sarataho E, Salonen R, Korpela H, et al. Eeefect of combined coenzyme Q10 and d-alpha-tocopherol acetate supplementation on exercise induced lipid peroxidation and muscular damage: A placebo- controlled double-blind study in marathon runners: Free Radic Res. 1998; 29: 85-92. [DOI:10.1080/10715769800300101]
44. Saha SP, Whayne TF.. Coenzyme Q10 in Human Health: Supporting Evidence? South Med J. 2016; 109(1):17-21. [DOI:10.14423/SMJ.0000000000000393]
45. O'Malley PA. The past, present, and future of coenzyme Q10 supplementation update for the clinical nurse specialist. Clin Nurse Spec. 2016; 30(1):15-26. [DOI:10.1097/NUR.0000000000000176]
46. Modir M, Daryanoosh F, Tanideh N, Mohamadi M, Firouzmand H. The effects of short and middle time's aerobic exercise with high intensities on ingredients antioxidant in female Sprague dawley rats. mjms.mums.ac. ir, 2014; 57(3) P: 587-595
47. Hagigholamali M, Jafari M, Asgari A.R, Haji Hossaini R, Abasnegad M, Salehi M, Salimian M. Effect of paraoxon on antioxidant system and lipid peroxidation in liver of rat: gums.ac.ir. 2009;75: 1-10
48. Jeffery N. Keller and Mark P. Mattson. Roles of Lipid Peroxidation in Modulation of Cellular Signaling Pathways, Cell Dysfunction, and Death in the Nervous System: Reviews in Neurosciences. 1998;.9:105-116 [DOI:10.1515/REVNEURO.1998.9.2.105]
49. Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q 10 as a potential treatment. Journal of bioenergetics and bio membranes. 2004; 36(4):381-6. [DOI:10.1023/B:JOBB.0000041772.74810.92]
50. Mattson MP. Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity. Trends in neurosciences. 1998; 21(2):53-7. [DOI:10.1016/S0166-2236(97)01188-0]
51. Dernbach AR, Sherman WM, Simonsen JC, Flowers KM, Lamb DR. No evidence of oxidant stress during high-intensity rowing training. Journal of Applied Physiology. 1993; 74(5):2140-5. [DOI:10.1152/jappl.1993.74.5.2140]
52. Powers SK, Ji LL, Leeu wenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Medicine and science in sports and exercise. 1999; 31(7):987-97. [DOI:10.1097/00005768-199907000-00011]
53. Akkus I. Free radical and their oatho- physiological efforts. 1st ed. Konya: Mimoza prints; 1995.p.27-31.
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Ebrahimi S, Haghighi A, Nikkhah K, Hamidi H. Effects of Coenzyme Q10 Supplementation on Antioxidant Enzyme and Lipid peroxide Activities in Women with Multiple Sclerosis: a Randomized, Placebo-controlled Trial. Iranian Journal of Nutrition Sciences & Food Technology. 2019; 14 (3) :11-20
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Volume 14, Issue 3 (Autumn 2019) Back to browse issues page
Iranian Journal of  Nutrition Sciences & Food  Technology
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