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Effects of Alpha-Lipoid Acid on Serum Iron, Total Iron Binding Capacity and Hematological Indices in β-Thalassemia Major Patients: A Cross Over Clinical Trial
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E Sharifi    , H Abdolahzad * , MR Golpayegani , Kh Jamshidi , M Aghdashi , MR Mohammad HoseiniAzar , Sh Falah |
| Kermanshah University of Medical Sciences , hadi_nut@yahoo.com |
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Abstract: (2142 Views) |
Background and Objectives: Accumulation of iron is the most common consequences of repeated blood transfusions in β-thalassemia major patients. Iron chelating effects of alpha-lipoic acid have been reported by several studies. The aim of this study was to investigate effects of supplementation with alpha-lipoic acid, as a chelator, on serum iron and hematological indices in these patients.
Materials & Methods: Twenty-two β-thalassemia major patients were selected to receive 600 mg alpha-lipoic acid or placebo capsules for 8 w. After a 3-week washout period, order of intervention was replaced as patients who previously received placebo were administered the supplement vise versa for another 8 w. At the end of the study, changes in serum iron, total iron binding capacity and hematological parameters between the treatments were assessed.
Results: Serum concentrations of iron and total iron binding capacity and hematological parameters did not change within the supplementation (p > 0.05). Changes in iron, total iron binding capacity and hematological indices were not significantly different between the two interventions (p > 0.05). White blood cell counts in placebo use increased significantly in males (p = 0.04). The mean corpuscular hemoglobin in placebo patients decreased significantly in all patients and males (p = 0.02 for both).
Conclusion: Results of this study revealed that alpha-lipoic acid supplementation included no beneficial effects on iron, total iron binding capacity and hematological indices in β-thalassemia major patients. Further studies with more participants and longer times are indispensable. |
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| Keywords: Beta-thalassemia, Iron overload, Thioctic acid, Cross-over study |
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Full-Text [PDF 606 kb]
(976 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2020/01/15 | Accepted: 2020/06/8 | Published: 2020/09/14
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