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:: Volume 20, Issue 2 (7-2025) ::
Iranian J Nutr Sci Food Technol 2025, 20(2): 7-16 Back to browse issues page
The Effect of 8 Weeks of High-Intensity Interval Running with Vitamin D Supplementation on VEGF and IL-6 Levels Women with Vitamin D Deficiency
B Rashidi , MaMasoumeh Habibian * , Seyyed Jafar Moosavi
Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran , habibian_m@yahoo.com
Abstract:   (301 Views)
Background and objectives: Obesity and vitamin D (VD)   deficiency are associated with endothelial dysfunction and systemic inflammation. The effect of execise training and VD intake in improving inflammation is considered. Therefore, in the current study, the effect of 8 weeks of high intensity interval running with vitamin Dsupplementation on the levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in sedentary young women with VD deficiency was investigated.
Materials and Methods:
In the present study, 39 overweight women (20-23 years) with VD deficiency were randomly divided into three groups: control, training, and training+VD (combined). High intensity interval training was performed in 12 one-minute repetitions of running with an intensity of 80-90% of the maximum heart rate and one minute of active rest with an intensity of 50% of the maximum heart rate, 3 sessions/week for 8 weeks. The combined group took VD (50000 IU) once a week. The levels of VEGF and IL-6 before and after 8 weeks were determined by ELISA method.
Results: Based on the results, serum levels of VEGF in the training and combination groups increased significantly (P<0.001) and IL-6 levels decreased significantly (P<0.001) compared to the control group. But the combined intervention has had a significant effect in comparison with other intervention on the changes of the variables (P<0.001).
Conclusion: It seems that any of the high intensity interval running interventions alone or combined with VD intake can lead to an increase in VEGF levels and a decrease in IL-6 in overweight women with VD deficiency, but combined intervention has been accompanied with stronger effects in improving endothelial function by reducing inflammation.
Keywords: High intensity interval training, IL-6, Overweight woman, VEGF, vitamin D deficiency
Full-Text [PDF 486 kb]   (66 Downloads)    
Article type: Research | Subject: nutrition
Received: 2024/10/19 | Accepted: 2024/11/20 | Published: 2025/07/14
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Rashidi B, Habibian M, Moosavi S J. The Effect of 8 Weeks of High-Intensity Interval Running with Vitamin D Supplementation on VEGF and IL-6 Levels Women with Vitamin D Deficiency. Iranian J Nutr Sci Food Technol 2025; 20 (2) :7-16
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Volume 20, Issue 2 (7-2025) Back to browse issues page
Iranian Journal of  Nutrition Sciences and Food  Technology
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