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:: Volume 20, Issue 3 (Autumn 2025) ::
Iranian J Nutr Sci Food Technol 2025, 20(3): 13-20 Back to browse issues page
The Effects of Core Stabilization Exercise and Vitamin D intake on the Levels of Tumor Necrosis Factor-α and Interleukin-10 in Women with Chronic Low Back Pain
M Biyabani , F Ghafari , S Aaali , M Habibian *
Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
Abstract:   (21 Views)
Background and Objectives: Chronic back pain is a multifactorial disease that can be affected by vitamin D deficiency, inflammatory conditions, and sedentary lifestyle. The aim of this study is to compare the effect of core stabilization exercises with vitamin D supplementation on the levels of tumor necrosis factor-alpha (TNF-α) and interleukin 10 (IL-10) in women with low back pain.
Materials & Methods: This semi-experimental study was conducted on 48 women suffering from chronic back pain, who were placed in 4 groups: control, exercise, vitamin D, and exercise + vitamin D. The exercise program included 6 core stabilization exercises performed in 3 sets with 8-10 repetitions and 1 minute rest between movements. Vitamin D was taken weekly with a dose of 50,000 international units. TNF-α  and IL-10 levels were measured before and after 8 weeks by ELISA method.
Results: Vitamin D levels in all subjects were lower than normal levels. 8 weeks of central stabilizing exercises, vitamin D and combined intervention led to a decrease in TNF-α serum levels and an increase in IL-10 (P<0.001). In addition, the effect of the combined intervention in increasing IL-10 was greater compared to the other two therapeutic interventions (P<0.001)
Conclusion: It seems that low levels of vitamin D are commen in patients with chronic back pain and performing central stabilization exercises, vitamin D consumption and a combination of these two interventions can lead to improvement of inflammation in people with back pain with low levels of vitamin D due to decrease TNF-α and positive regulation of IL-10.
Keywords: : Interleukin-10, Tumor necrosis factor-alpha, Low Back Pain, Vitamin D
Full-Text [PDF 736 kb]   (11 Downloads)    
Article type: Research | Subject: nutrition
Received: 2024/12/18 | Accepted: 2025/03/2 | Published: 2025/10/12
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Biyabani M, Ghafari F, Aaali S, Habibian M. The Effects of Core Stabilization Exercise and Vitamin D intake on the Levels of Tumor Necrosis Factor-α and Interleukin-10 in Women with Chronic Low Back Pain. Iranian J Nutr Sci Food Technol 2025; 20 (3) :13-20
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