[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Issue 1 (Spring 2016) ::
2016, 11(1): 1-10 Back to browse issues page
The Effect of Synbiotic Gaz Fortified with Beta-carotene Consumption on Glycemic Control and Blood Lipids of Patients with Type 2 Diabetes
F Sayyedi, Z Asemi *, M Goli, F Bahmani, S Alizadeh, A Esmaillzadeh
Kashan University of Medical Sciences
Abstract:   (5467 Views)

Background & Objectives: Recent evidence suggests that antioxidants and synbiotics intake due to the effect on inflammatory cytokines and oxidative stress may affect the glycemic control and blood lipids of diabetic patients. The aim of study was to investigate the effect of synbiotic Gaz fortified with beta-carotene consumption on metabolic profile among patients with type 2 diabetes (T2D).

Materials and Methods: This randomized double-blinded cross-over controlled clinical trial was conducted among 51 patients with T2D aged 35-70 y. After a 2-wk run-in period, the individuals were randomly assigned to consume either a synbiotic Gaz fortified with beta-carotene (n=51) or control food (n=51) for 6 weeks. A 3-week washout period was applied; then the subjects were crossed over to the alternate treatment arm for an additional 6 weeks. The synbiotic Gaz fortified with beta-carotene contained a probiotic viable and heat-resistance strain Lactobacillus sporogenes (1×107 CFU), 0.15 g inulin as prebiotic and 0.04 g beta-carotene. The control food (the same substance without probiotic bacteria, prebiotic inulin and beta-carotene) was packed in identical 7-gram packages. The patients were asked to consume the synbiotic or control Gaz three times a day. Fasting blood samples were taken at baseline and after 6-wk phase of intervention to measure the metabolic profile.

Results: After 6 weeks of intervention, synbiotic Gaz fortified with beta-carotene consumption compared with the control Gaz has resulted in a significant decrease in serum insulin (changes from baseline:
 -1.00±7.90 vs. +3.68±6.91 µIU/mL, P=0.002), HOMA-IR (-0.73±3.96 vs. +1.82±4.09, P=0.002), HOMA-B (-0.52±19.75 vs. +8.71±17.15, P=0.01), triglycerides (-2.86±49.53 vs. +20.14±50.10 mg/dL, P=0.02), VLDL-cholesterol (-0.57±9.90 vs. +4.03±10.02 mg/dL, P=0.02) and total-/HDL-cholesterol ratio
(-0.01±1.08 vs. +0.64±0.81, P=0.001).

Conclusion: In conclusion, consumption of the synbiotic Gaz fortified with beta-carotene for 6 weeks among the T2D patients compared with the control Gaz had beneficial effects on the serum insulin concentrations, insulin resistance, triglycerides, VLDL-cholesterol, and total-/HDL-cholesterol, but not on other biochemical profiles. 

Keywords: Synbiotic, Insulin resistance, Glycemic control, Blood lipid, Type 2 diabetes

Keywords: Synbiotic, Insulin resistance, Glycemic control, Blood lipid, Type 2 diabetes
Full-Text [PDF 219 kb]   (1544 Downloads)    
Type of Study: Research | Subject: nutrition
Received: 2015/06/7 | Accepted: 2015/09/6 | Published: 2016/04/6
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sayyedi F, Asemi Z, Goli M, Bahmani F, Alizadeh S, Esmaillzadeh A. The Effect of Synbiotic Gaz Fortified with Beta-carotene Consumption on Glycemic Control and Blood Lipids of Patients with Type 2 Diabetes. Iranian Journal of Nutrition Sciences & Food Technology. 2016; 11 (1) :1-10
URL: http://nsft.sbmu.ac.ir/article-1-1938-en.html


Volume 11, Issue 1 (Spring 2016) Back to browse issues page
Iranian Journal of  Nutrition Sciences & Food  Technology
Persian site map - English site map - Created in 0.07 seconds with 32 queries by YEKTAWEB 4071