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:: Volume 14, Issue 3 (Autumn 2019) ::
2019, 14(3): 31-40 Back to browse issues page
Effects of Resistance Training and HMB Supplementation on Responses of hs-CRP and Lipid Profiles to Strenuous Activity in Adult Male Rats
F Aghaei , S Shadmehri , A Soleymani
Islamic Azad University
Abstract:   (390 Views)
Background and Objectives: Various types of exercise cause damages at cellular levels in muscles. Muscle damages caused by exercise increase levels of C-reactive protein (CRP) in blood. The aim of this study was to assess effects of resistance training and ta-hydroxy beta-methylbutyric acid (HMB) supplementation on responses of high sensitivity C-reactive protein (hs-CRP) and lipid profiles to strenuous activity in adult male rats.
 Materials & Methods: In total, 32 healthy rat were randomly divided into four major groups of training, supplement, training-supplement and control groups. The experimental group carried out eccentric resistance for two weeks, five days a week. Supplementary groups received supplemental HMB daily for up to 450 mg/kg body weight per day using gavage. In general, one session of strenuous eccentric resistance activity (stepping down from ladder with a gradient of 80% by closing 120% 1RM at the back of the rat tails) was carried out 24 h before and after the intervention (supplementary and training). Data analysis was carried out using ANOVA and Tukey post hoc test at P ≤ 0.05.
Results: Results showed that HMB supplementation and eccentric resistance training alone included no effects on hs-CRP, cholesterol, triglycerides, LDL-C and HDL-C in adult male rats after strenuous activity (P < 0.05). However, combination of HMB supplementation and eccentric resistance training included a significant effect on these variables after a strenuous activity in adult male rats (P= 0.001).
Conclusion: Based on the results, combination of supplemental HMB and eccentric resistance training may help improve inflammatory statuses and lipid profiles.
Keywords: Supplements HMB, Eccentric resistance training, hs-CRP, Lipid profile
Full-Text [PDF 787 kb]   (199 Downloads)    
Type of Study: Research | Subject: nutrition
Received: 2018/10/17 | Accepted: 2020/01/24 | Published: 2019/10/7
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Aghaei F, Shadmehri S, Soleymani A. Effects of Resistance Training and HMB Supplementation on Responses of hs-CRP and Lipid Profiles to Strenuous Activity in Adult Male Rats. Iranian Journal of Nutrition Sciences & Food Technology. 2019; 14 (3) :31-40
URL: http://nsft.sbmu.ac.ir/article-1-2739-en.html

Volume 14, Issue 3 (Autumn 2019) Back to browse issues page
Iranian Journal of  Nutrition Sciences & Food  Technology
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