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The effect of Aerobic Exercise and Resveratrol on Hippocampal Neurotrophin Levels of Rats with Alzheimer's Disease
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F Babajani    , S Farajtabar Behrestaq * , A Taghipoor |
| Qaemshahr Branch, Islamic Azad University , s.faraj.b@iau.ac.ir |
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Abstract: (9 Views) |
Background and Objectives: Promoting regular exercise and a diet containing polyphenols are effective non-pharmacological approaches that prevent the progression of neurodegenerative diseases. The aim of this study was to investigate the effect of aerobic exercise and resveratrol on the levels of neurotrophins in the hippocampus of Alzheimer's rats.
Materials & Methods: In this experimental study, 35 8-week-old male Wistar rats with a mean weight of 217.25±6.07 g were divided into five groups: normal (NO), Alzheimer's (AD), Alzheimer's-training (ADT), Alzheimer's-resveratrol (ADRSV), and Alzheimer's-training-resveratrol (ADTRSV). The supplement groups received 20 mg of RSV (per kg of body weight) orally during the intervention period. Amyloid beta 42-1 purchased from Sigma-Aldridge was used to induce Alzheimer's. Aerobic exercise program including running on treadmill with a speed of 6-18 meters per minute, was performed 5 days a week for eight weeks. Finally, to compare the mean changes of the research variables, one-way analysis of variance test and Tukey's post hoc test were used at a significance level of p≤0.05.
Results: AD induction decreased the expression of BDNF and NGF (p=0.0001). The expression of BDNF and NGF increased significantly in ADT (p=0.028 and p=0.029, respectively), ADRSV (p=0.047 and p=0.044, respectively) and ADTRSV (p=0.0001 and p=0.0001, respectively). The increase in BDNF expression was significant in ADTRSV compared to ADT group (p=0.040) and ADRSV (p=0.023).
Conclusion: Aerobic exercise and RSV in AD rat led to the increase of BDNF and NGF, which indicates the neuroprotection of exercise and RSV on AD disease. However, the effect of the combination of exercise and RSV was greater than either alone. |
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| Keywords: Exercise, Resveratrol, Neurotrophin, Hippocampus, Alzheimer's |
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Full-Text [PDF 854 kb]
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Article type: Research |
Subject:
nutrition
Received: 2025/07/29 | Accepted: 2025/10/13
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