1. Ullah R, Zafar MS, Shahani N. Potential fluoride toxicity from oral medicaments: A review. Iranian journal of basic medical sciences. 2017;20(8):841.

2. Organization WH. Guidelines for drinking-water quality: World Health Organization; 2002.

3. Jaiswal P, Mandal M, Mishra A. Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats. Journal of Biochemical and Molecular Toxicology. 2020;34(11):e22575. [DOI:10.1002/jbt.22575]

4. Akinrinde AS, Tijani M, Awodele OA, Oyagbemi AA. Fluoride-induced hepatotoxicity is prevented by L-Arginine supplementation via suppression of oxidative stress and stimulation of nitric oxide production in rats. Toxicology and Environmental Health Sciences. 2021;13:57-64. [DOI:10.1007/s13530-020-00070-6]

5. Wei Q, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. A mini review of fluoride-induced apoptotic pathways. Environmental Science and Pollution Research. 2018;25:33926-35. [DOI:10.1007/s11356-018-3406-z]

6. Chen J, Niu Q, Xia T, Zhou G, Li P, Zhao Q, et al. ERK1/2-mediated disruption of BDNF-TrkB signaling causes synaptic impairment contributing to fluoride-induced developmental neurotoxicity. Toxicology. 2018;410:222-30. [DOI:10.1016/j.tox.2018.08.009]

7. Dong N, Feng J, Xie J, Tian X, Li M, Liu P, et al. Co-exposure to arsenic-fluoride results in endoplasmic reticulum stress-induced apoptosis through the PERK signaling pathway in the liver of offspring rats. Biological trace element research. 2020;197:192-201. [DOI:10.1007/s12011-019-01975-1]

8. Ribeiro DA, Yujra VQ, da Silva VHP, Claudio SR, Estadella D, de Barros Viana M, et al. Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review. Environmental Science and Pollution Research. 2017;24:15254-9. [DOI:10.1007/s11356-017-9105-3]

9. Rocha-Amador D, Navarro ME, Carrizales L, Morales R, Calderón J. Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Cadernos de saúde pública. 2007;23(suppl 4):S579-S87. [DOI:10.1590/S0102-311X2007001600018]

10. Spittle B. Psychopharmacology of fluoride: a review. International clinical psychopharmacology. 1994;9(2):79-82. [DOI:10.1097/00004850-199400920-00002]

11. Inkielewicz-Stepniak I, Czarnowski W. Oxidative stress parameters in rats exposed to fluoride and caffeine. Food and Chemical Toxicology. 2010;48(6):1607-11. [DOI:10.1016/j.fct.2010.03.033]

12. Darvesh AS, Carroll RT, Bishayee A, Novotny NA, Geldenhuys WJ, Van der Schyf CJ. Curcumin and neurodegenerative diseases: a perspective. Expert opinion on investigational drugs. 2012;21(8):1123-40. [DOI:10.1517/13543784.2012.693479]

13. Manthey JA, Guthrie N, Grohmann K. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Current medicinal chemistry. 2001;8(2):135-53. [DOI:10.2174/0929867013373723]

14. Hirata A, Murakami Y, Shoji M, Kadoma Y, Fujisawa S. Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer research. 2005;25(5):3367-74.

15. Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC. 6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Pharmacology Biochemistry and Behavior. 2003;75(3):537-45. [DOI:10.1016/S0091-3057(03)00121-7]

16. Wang Y, Duan L, Zhang X, Jiao Y, Liu Y, Dai L, et al. Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum. Ecotoxicology and environmental safety. 2021;224:112691. [DOI:10.1016/j.ecoenv.2021.112691]

17. Hu J, Li C, Hua Y, Liu P, Gao B, Wang Y, et al. Constraint-induced movement therapy improves functional recovery after ischemic stroke and its impacts on synaptic plasticity in sensorimotor cortex and hippocampus. Brain research bulletin. 2020;160:8-23. [DOI:10.1016/j.brainresbull.2020.04.006]

18. Gao Q, Liu Y-J, Guan Z-Z. Decreased learning and memory ability in rats with fluorosis: increased oxidative stress and reduced cholinesterase activity in the brain. Fluoride. 2009;42(4):277.

19. Wang J, Gao Y, Cheng X, Yang J, Zhao Y, Xu H, et al. GSTO1 acts as a mediator in sodium fluoride-induced alterations of learning and memory related factors expressions in the hippocampus cell line. Chemosphere. 2019;226:201-9. [DOI:10.1016/j.chemosphere.2019.03.144]

20. Banala RR, Karnati PR. Vitamin A deficiency: An oxidative stress marker in sodium fluoride (NaF) induced oxidative damage in developing rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2015;47(Pt B):298-303. [DOI:10.1016/j.ijdevneu.2015.08.010]

21. Justin-Thenmozhi A, Dhivya Bharathi M, Kiruthika R, Manivasagam T, Borah A, Essa MM. Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3β Pathway by Hesperidin in Wistar Rats. Neurotoxicity Research. 2018;34(3):463-76. [DOI:10.1007/s12640-018-9904-4]

22. Atmaca N, Atmaca HT, Kanici A, Anteplioglu T. Protective effect of resveratrol on sodium fluoride-induced oxidative stress, hepatotoxicity and neurotoxicity in rats. Food and Chemical Toxicology. 2014;70:191-7. [DOI:10.1016/j.fct.2014.05.011]

23. Noorafshan A, Vafabin M, Karbalay-Doust S, Asadi-Golshan R. Efficacy of curcumin in the modulation of anxiety provoked by sulfite, a food preservative, in rats. Preventive Nutrition and Food Science. 2017;22(2):144.

24. Noorafshan A, Abdollahifar M-A, Karbalay-Doust S, Asadi-Golshan R, Rashidian-Rashidabadi A. Protective effects of curcumin and sertraline on the behavioral changes in chronic variable stress-induced rats. Experimental neurobiology. 2013;22(2):96. [DOI:10.5607/en.2013.22.2.96]

25. Bartos M, Gumilar F, Baier CJ, Dominguez S, Bras C, Cancela LM, et al. Rat developmental fluoride exposure affects retention memory, leads to a depressive-like behavior, and induces biochemical changes in offspring rat brains. Neurotoxicology. 2022;93:222-32. [DOI:10.1016/j.neuro.2022.10.006]

26. Nadei OV, Agalakova NI. AMPA and NMDA Receptors in Hippocampus of Rats with Fluoride-Induced Cognitive Decline. International Journal of Molecular Sciences. 2024;25(21):11796. [DOI:10.3390/ijms252111796]

27. Enríquez-Sánchez FM, Pérez-Vega MI, Miranda-Beltrán MdlL, Valdez-Jiménez L. Effects of Long-Term Fluoride Exposure: Systematic Review and Meta-Analysis on Anxiety and Depression in Animal Models. Biological Trace Element Research. 2025;204(3):1393-1416. [DOI:10.1007/s12011-025-04755-2]

28. Lee B, Choi GM, Sur B. Antidepressant-like effects of hesperidin in animal model of post-traumatic stress disorder. Chinese journal of integrative medicine. 2021;27(1):39-46. [DOI:10.1007/s11655-020-2724-4]

29. Gölboyu BE, Erdoğan MA, Çoşar MA, Balıkoğlu E, Erbaş O. Diosmin and hesperidin have a protective effect in diabetic neuropathy via the FGF21 and Galectin-3 pathway. Medicina. 2024;60(10):1580. [DOI:10.3390/medicina60101580]

30. Olasehinde TA, Ekundayo TC, Ijabadeniyi OA, Olaniran AO. The Impact of Hesperidin on Cognitive Deficit and Neurobehavioural Disorders: A Systematic Review and Meta-Analysis of Preclinical Individual Studies. Current Behavioral Neuroscience Reports. 2024;11(4):246-59. [DOI:10.1007/s40473-024-00284-9]

31. Dec K, Łukomska A, Skonieczna-Żydecka K, Jakubczyk K, Tarnowski M, Lubkowska A, et al. Chronic exposure to fluoride affects GSH level and NOX4 expression in rat model of this element of neurotoxicity. Biomolecules. 2020;10(3):422. [DOI:10.3390/biom10030422]

32. Hamza RZ, El-Shenawy NS, Ismail HA. Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat. Journal of Basic and Clinical Physiology and Pharmacology. 2015;26(3):237-51. [DOI:10.1515/jbcpp-2014-0065]

33. Oyagbemi AA, Adebiyi OE, Adigun KO, Ogunpolu BS, Falayi OO, Hassan FO, et al. Clofibrate, a PPAR‐α agonist, abrogates sodium fluoride‐induced neuroinflammation, oxidative stress, and motor incoordination via modulation of GFAP/Iba‐1/anti‐calbindin signaling pathways. Environmental toxicology. 2020;35(2):242-53. [DOI:10.1002/tox.22861]

34. Umarani V, Muvvala S, Ramesh A, Lakshmi B, Sravanthi N. Rutin potentially attenuates fluoride-induced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats. Toxicology mechanisms and methods. 2015;25(2):143-9. [DOI:10.3109/15376516.2014.1003359]

35. Sharma P, Verma PK, Sood S, Singh R, Gupta A, Rastogi A. Distribution of fluoride in plasma, brain, and bones and associated oxidative damage after induced chronic fluorosis in Wistar rats. Biological trace element research. 2022;200(4):1710-21. [DOI:10.1007/s12011-021-02782-3]

36. Maity PP, Dash M, Dey A, Maity M, Chattopadhyay S, editors. Vitamin C and E in fluoride induced uterine oxidative stress and apoptotic gene expression in Wistar rats. Proceedings of the Zoological Society; 2021: Springer. [DOI:10.1007/s12595-021-00362-w]

37. Wen P, Wei X, Liang G, Wang Y, Yang Y, Qin L, et al. Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers. Environmental Science and Pollution Research. 2019;26:2671-80. [DOI:10.1007/s11356-018-3726-z]

38. Talebinasab A, Javanbakht P, Mojaverrostami S, Ragerdi Kashani I, Keshavarz L, Hashemi M, et al. Hesperidin protects against sodium fluoride-induced molecular, stereological, and behavioral alterations in the rat cerebellum. Nutritional Neuroscience. 2026;29(5):559-78. [DOI:10.1080/1028415X.2025.2575810]

39. Yıldız MO, Çelik H, Caglayan C, Kandemir FM, Gür C, Bayav İ, et al. Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy. NeuroToxicology. 2022;90:197-204. [DOI:10.1016/j.neuro.2022.04.002]

40. Kosari-Nasab M, Shokouhi G, Ghorbanihaghjo A, Abbasi MM, Salari A-A. Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury. Life Sciences. 2018;213:198-205. [DOI:10.1016/j.lfs.2018.10.040]