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:: Volume 11, Issue 4 (Winter 2017) ::
Iranian J Nutr Sci Food Technol 2017, 11(4): 47-54 Back to browse issues page
The Effect of Creatine Monohydrate Supplementation on Apoptosis at Acute Resistance Exercise in Middle-aged Men
V Sari Sarraf, R Amirsasan, D Shekholeslami Vatani, H Faraji *
Department of Physical Education and Sports Science, Marivan Branch, Islamic Azad University, Marivan, Iran.
Abstract:   (4993 Views)

Background and Objectives: The effect of creatine monohydrate loading on exercise-induced apoptosis is unclear. The purpose of this study was to examine the effect of creatine supplementation on apoptosis at acute resistance exercise in men.

Materials and Methods: In a randomized, placebo controlled, clinical trial study, twenty 42-49 middle-aged year men were randomly assigned to supplement with 20 g per day of creatine monohydrate or placebo (maltodextrin) similarly for one week. On the 8th day, the subjects performed an acute resistance exercise with 80% of one repetition maximum. Blood samples were collected a day before supplementation loading (Pre) and immediately post-acute exercise (Post) for the measurement of serum p53, caspase 8 and Insulin-like growth factor 1 (IGF-1) concentrations. Data were analyzed by Student’s paired and unpaired t tests at the significant level of P<0.05.

Results: P53 serum [Pre: 486.41±40.98, Post: 842.20±170.86 ng/L (p=.000)] and caspase 8 [Pre=8.36±1.26, Post: 11.66±4.15 ng/ml (p=.031)] levels were significantly increased in the placebo group immediately post-acute exercise. Also IGF-1 was significantly increased in both groups. The p53 level was significantly higher in the placebo group as compared to the creatine group immediately post-acute exercise (P<0.05).

Conclusion: The results indicated that creatine monohydrate loading can inhibit acute resistance-induced apoptosis in middle-aged. Thus, one week creatine supplementation may be a useful strategy for preventing apoptosis by extensive acute exercise.

Keywords: Apoptosis, Creatine monohydrate, Caspase 8, p53, Resistance exercise

Keywords: Apoptosis, Creatine monohydrate, Caspase 8, p53, Resistance exercise
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Article type: Research | Subject: nutrition
Received: 2016/04/11 | Accepted: 2016/08/9 | Published: 2016/12/28
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Sari Sarraf V, Amirsasan R, Shekholeslami Vatani D, Faraji H. The Effect of Creatine Monohydrate Supplementation on Apoptosis at Acute Resistance Exercise in Middle-aged Men . Iranian J Nutr Sci Food Technol. 2017; 11 (4) :47-54
URL: http://nsft.sbmu.ac.ir/article-1-2201-en.html


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Volume 11, Issue 4 (Winter 2017) Back to browse issues page
Iranian Journal of  Nutrition Sciences & Food  Technology
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