[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
this is a test
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
Subscription::
Contact us::
Site Facilities::
Webmail::
Ethical Consideration::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 19, Issue 3 (Autumn 2024) ::
Iranian J Nutr Sci Food Technol 2024, 19(3): 96-105 Back to browse issues page
Effects of Camel Milk on Glycemic Indices and Lipid Profiles of Type-1 and Type-2 Diabetic and Metabolic Syndrome Patients: A Systematic Review
M Navvab , S Hosseinpour-Niazi * , P Mirmiran , J Mirzay Razzaz , F Azizi
Endocrine Research Center , s.hossainpour@yahoo.com
Abstract:   (237 Views)
Background and Objectives: This study was carried out on camel milk consumption to improve risk factors of type 1 and 2 diabetes and metabolic syndrome. The purpose of this systematic review was to assess effects of camel milk on glycemic indices and blood lipid profiles in patients with metabolic syndrome and type-1 and type-2 diabetes.
 Materials & Methods: To extract original English articles published until May 2023 without limiting the year of publication, Scopus and PubMed databases were searched using the following keywords of “metabolic syndrome” or “type 1 diabetes” or “type 2 diabetes” or “lipid profile” or “insulin” or “fasting blood glucose”  or “HbA1c” and “camel milk”.
Results: From 73 studies, 11 studies were included in the present systematic review .Seven studies assessed fasting blood sugar levels and in three studies, fasting blood sugar levels decreased after consuming camel milk. Moreover, seven studies assessed levels of HbA1c and in four studies, levels of HbA1c decreased significantly. Six studies investigated doses of insulin. In five studies, levels of insulin dose in the camel milk consumption group significantly decreased, compared to the beginning of the study. Furthermore, eight studies assessed the blood levels and in most of these studies, blood profiles changed.
Conclusion: Results of the consumption of camel milk on glycemic indices and blood lipid profiles were contradictory. It is necessary to carry out clinical trial studies with longer times and larger sample sizes.
Keywords: Camel milk, Diabetes, Metabolic syndrome, Blood sugar, Lipid profile
Full-Text [PDF 782 kb]   (132 Downloads)    
Article type: Review | Subject: nutrition
Received: 2023/12/5 | Accepted: 2024/07/10 | Published: 2024/10/2
References
1. Alberti K, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Joint scientific statement. Circulation. 2009;120:1640-5. [DOI:10.1161/CIRCULATIONAHA.109.192644]
2. Gebreegziabiher G, Belachew T, Mehari K, Tamiru D. Magnitude and associated factors of metabolic syndrome among adult urban dwellers of Northern Ethiopia. Diabetes Metab Syndr Obes. 2021; 14: 589-600. [DOI:10.2147/DMSO.S287281]
3. Gemeda D, Abebe E, Duguma A. Metabolic Syndrome and Its Associated Factors among Type 2 Diabetic Patients in Southwest Ethiopia, 2021/2022. J Diabetes Res. 2022;2022: 8162342. [DOI:10.1155/2022/8162342]
4. Li W, Qiu X, Ma H, Geng Q. Incidence and long-term specific mortality trends of metabolic syndrome in the United States. Front Endocrinol. 2023; 13: 1029736. [DOI:10.3389/fendo.2022.1029736]
5. Navvab M, Hosseinpour-Niazi S, Mirmiran P, Mirzay Razaz J, Azizi F. Relationship between the Consumption of Refined and Whole Grains and the Risk of Metabolic Syndrome Components in Adults: The Tehran Lipid and Glucose Study. IJEM. 2022;24(3):156-66.
6. Larejani B, Zahedi F. Epidemiology of diabetes mellitus in Iran. Iranian Journal of Diabetes and Lipid Disorders. 2001;1(1):1-8.
7. Mirmiran P, Niasari Naslaji A, Moosavi Movahedi A, Eslami F, Azizi F. Effect of camel milk on glycemic control and lipid profiles of diabetic patients. IJEM. 2017;19(4):223-33.
8. Agrawal RP, Sharma P, Gafoorunissa SJ, Ibrahim SA, Shah B, Shukla D, et al. Effect of camel milk on glucose metabolism in adults with normal glucose tolerance and type 2 diabetes in Raica community: a crossover study. Acta Biomed. 2011;82(3):181-6.
9. Bommer C, Heesemann E, Sagalova V, Manne-Goehler J, Atun R, Barnighausen T, et al. The global economic burden of diabetes in adults aged 20-79 years: a cost-of-illness study. Lancet Diabetes Endocrinol 2017; 5(6): 423-30. [DOI:10.1016/S2213-8587(17)30097-9]
10. Park Y, Lee SJ. Analysis of the Association between Metabolic Syndrome and Renal Function in Middle-Aged Patients with Diabetes. Int J Environ Res Public Health. 2022;19(18):11832. [DOI:10.3390/ijerph191811832]
11. Kaskous S. Importance of camel milk for human health. Emirates Journal of Food and Agriculture. 2016:158-63. [DOI:10.9755/ejfa.2015-05-296]
12. Abdalla K. An overview of the therapeutic effects of camel milk in the treatment of type 1 diabetes mellitus. Biomol Res Therap. 2014;3:118-24.
13. Malik A, Al-Senaidy A, Skrzypczak-Jankun E, Jankun J. A study of the anti-diabetic agents of camel milk. Int J Mol Med. 2012; 30(3): 585-92. [DOI:10.3892/ijmm.2012.1051]
14. Agrawal R, Jain S, Shah S, Chopra A, Agarwal V. Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial. Eur J Clin Nutr. 2011;65(9):1048-52. [DOI:10.1038/ejcn.2011.98]
15. Abdulrahman AO, Ismael MA, Al-Hosaini K, Rame C, Al-Senaidy AM, Dupont J, et al. Differential effects of camel milk on insulin receptor signaling-toward understanding the insulin-like properties of camel milk. Front Endocrinol. 2016; 7: 4. [DOI:10.3389/fendo.2016.00004]
16. AlKurd R, Hanash N, Khalid N, Abdelrahim DN, Khan MA, Mahrous L, et al. Effect of camel milk on glucose homeostasis in patients with diabetes: A systematic review and meta-analysis of randomized controlled trials. Nutrients. 2022;14(6):1245. [DOI:10.3390/nu14061245]
17. Mohammadabadi T. Camel milk as an amazing remedy for health complications: a review. Basrah Journal of Agricultural Sciences. 2020;33(2):125-37. [DOI:10.37077/25200860.2020.33.2.11]
18. Mirmiran P, Ejtahed H-S, Angoorani P, Eslami F, Azizi F. Camel milk has beneficial effects on diabetes mellitus: A systematic review. Int J Endocrinol Metab. 2017;15(2):e42150. [DOI:10.5812/ijem.42150]
19. Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016; 355: i4919. [DOI:10.1136/bmj.i4919]
20. Sterne JA, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366: l4898. [DOI:10.1136/bmj.l4898]
21. Ejtahed HS, Naslaji AN, Mirmiran P, Yeganeh MZ, Hedayati M, Azizi F, et al. Effect of camel milk on blood sugar and lipid profile of patients with type 2 diabetes: a pilot clinical trial. Int J Endocrinol Metab. 2015; 13(1): e21160. [DOI:10.5812/ijem.21160]
22. Fallah Z, Feizi A, Hashemipour M, Kelishadi R. Positive effect of fermented camel milk on liver enzymes of adolescents with metabolic syndrome: a double blind, randomized, cross-over trial. Mater SocioMed. 2018;30(1):20-5. [DOI:10.5455/msm.2018.30.20-25]
23. Fallah Z, Feizi A, Hashemipour M, Kelishadi R. Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial. J Res Med Sci. 2018; 23: 32. [DOI:10.4103/jrms.JRMS_1191_17]
24. Agrawal RP, Dogra R, Mohta N, Tiwari R, Singhal S, Sultania S. Beneficial effect of camel milk in diabetic nephropathy. Acta Biomed. 2009;80(2):131-4.
25. Agarwal R, Swami S, Beniwal R, Kochar D, Sahani M, Tuteja F, et al. Effect of camel milk on glycemic control, risk factors and diabetes quality of life in type-1 diabetes: A randomized prospective controlled study. Journal of Camel Practice and Research. 2003;10(1):45-50.
26. Agrawal R, Beniwal R, Kochar D, Tuteja F, Ghorui S, Sahani M, et al. Camel milk as an adjunct to insulin therapy improves long-term glycemic control and reduction in doses of insulin in patients with type-1 diabetes: a 1 year randomized controlled trial. Diabetes Res Clin Pract. 2005; 68(2): 176-7. [DOI:10.1016/j.diabres.2004.12.007]
27. Mohamad RH, Zekry ZK, Al-Mehdar HA, Salama O, El-Shaieb SE, El-Basmy AA, et al. Camel milk as an adjuvant therapy for the treatment of type 1 diabetes: verification of a traditional ethnomedical practice. J Med Food. 2009; 12(2): 461-5. [DOI:10.1089/jmf.2008.0009]
28. Zheng Y, Wu F, Zhang M, Fang B, Zhao L, Dong L, et al. Hypoglycemic effect of camel milk powder in type 2 diabetic patients: A randomized, double‐blind, placebo‐controlled trial. Food Sci Nutr. 2021; 9(8): 4461-72. [DOI:10.1002/fsn3.2420]
29. Shori AB. Camel milk as a potential therapy for controlling diabetes and its complications: A review of in vivo studies. J Food Drug Anal. 2015; 23(4): 609-18. [DOI:10.1016/j.jfda.2015.02.007]
30. Hussain H, Wattoo FH, Wattoo MHS, Gulfraz M, Masud T, Shah I, et al. Camel milk as an alternative treatment regimen for diabetes therapy. Food Sci Nutr. 2021; 9(3): 1347-56. [DOI:10.1002/fsn3.2078]
31. Aqib AI, Kulyar MF-e-A, Ashfaq K, Bhutta ZA, Shoaib M, Ahmed R. Camel milk insuline: Pathophysiological and molecular repository. Trends in Food Science & Technology. 2019;88:497-504. [DOI:10.1016/j.tifs.2019.04.009]
32. Ayoub MA, Palakkott AR, Ashraf A, Iratni R. The molecular basis of the anti-diabetic properties of camel milk. Diabetes Res Clin Pract. 2018; 146: 305-12. [DOI:10.1016/j.diabres.2018.11.006]
33. Badr G, Sayed LH, Omar HE-DM, Abd El-Rahim AM, Ahmed EA, Mahmoud MH. Camel whey protein protects B and T cells from apoptosis by suppressing activating transcription factor-3 (ATF-3)-mediated oxidative stress and enhancing phosphorylation of AKT and IκB-α in type I diabetic mice. Cell Physiol Biochem. 2017; 41(1): 41-54. [DOI:10.1159/000455935]
34. DiGiacomo K, Zamuner F, Sun Y, Dunshea F, Raynes J, Leury B. Effects of Raw and Pasteurized Camel Milk on Metabolic Responses in Pigs Fed a High-Fat Diet. Animals (Basel) 2022; 12 (13), 1701. [DOI:10.3390/ani12131701]
35. Agrawal RP, Saran S, Sharma P, Gupta RP, Kochar DK, Sahani MS. Effect of camel milk on residual β-cell function in recent onset type 1 diabetes. Diabetes Res Clin Prac. 2007;77(3):494-5. [DOI:10.1016/j.diabres.2007.01.012]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Navvab M, Hosseinpour-Niazi S, Mirmiran P, Mirzay Razzaz J, Azizi F. Effects of Camel Milk on Glycemic Indices and Lipid Profiles of Type-1 and Type-2 Diabetic and Metabolic Syndrome Patients: A Systematic Review. Iranian J Nutr Sci Food Technol 2024; 19 (3) :96-105
URL: http://nsft.sbmu.ac.ir/article-1-3778-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 19, Issue 3 (Autumn 2024) Back to browse issues page
Iranian Journal of  Nutrition Sciences and Food  Technology
Persian site map - English site map - Created in 0.04 seconds with 37 queries by YEKTAWEB 4660