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:: Volume 19, Issue 3 (Autumn 2024) ::
Iranian J Nutr Sci Food Technol 2024, 19(3): 11-20 Back to browse issues page
Effects of Eight Weeks of Intense Aerobic Training and Cinnamon Extract on Gene Expression of SREBP-1c and LXRα in the Liver Tissue of Rats Fed with Fructose Diets
F Mamashli , S Farajtabar Behrestaq * , B Askari , A Taghipour , A Askari
Qaemshahr Branch, Islamic Azad University , farajtabarp@yahoo.com
Abstract:   (283 Views)
Background and Objectives: Although LXRα and SREBP-1C are involved in lipid metabolism and liver injury, mechanisms of their modulation following exercise and herbal supplement consumption are less investigated. The aim of the present study was to investigate effects of 8 w of aerobic exercise and cinnamon extract on the expression of SREBP-1c and LXRα in the liver tissue of mice fed with fructose.
 Materials & Methods: To carry out the present experimentally practical study, 32 6-w-old male rats with an average weight of 154.66 g ±10.95 and insulin resistant by feeding 10% fructose solution for 5 w were randomly divided into four control (IRC), exercise (IRT), cinnamon extract (IRCi) and exercise-cinnamon extract (IRTCi) groups. The training program was implemented for 8 w with 5 d each week with an intensity of 75–80% VO2max from 10–15 min in the first week to 60 min in the last week. The IRCi and IRTCi groups were injected daily with 200 ml/kg cinnamon extract. After 8 w, rats were sacrificed and the variables were assessed using real-time polymerase chain reaction.
Results: Significant decreases in SREBP-1c expression were seen in IRT (p = 0.032), IRCi (p = 0.045) and IRTCi (p = 0.005) groups, compared to IRC. The expression of LXRα in the IRT (p=0.022), IRCi (p=0.024) and IRTCi (p=0.0001) groups had a significant increase compared to the IRC group. In addition, a significant increase in LXRα expression was observed in IRTCi groups compared to IRT (p=0.048) and IRCi (p=0.044) groups.
Conclusion: Results verified effects of aerobic exercise and cinnamon extract alone and in combination with each other on the expression of genes affecting fat metabolism and lipogenesis as well as greater interactive effects on the LXRα variable. Therefore, it is recommended to use exercises and supplements with caution.
Keywords: Aerobic exercise, Cinnamon extract, Fructose, LXRα, SREBP-1c, Liver
Full-Text [PDF 888 kb]   (125 Downloads)    
Article type: Research | Subject: nutrition
Received: 2024/05/8 | Accepted: 2024/07/1 | Published: 2024/10/2
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Mamashli F, Farajtabar Behrestaq S, Askari B, taghipour A, Askari A. Effects of Eight Weeks of Intense Aerobic Training and Cinnamon Extract on Gene Expression of SREBP-1c and LXRα in the Liver Tissue of Rats Fed with Fructose Diets. Iranian J Nutr Sci Food Technol 2024; 19 (3) :11-20
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Volume 19, Issue 3 (Autumn 2024) Back to browse issues page
Iranian Journal of  Nutrition Sciences and Food  Technology
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