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The effects of omega-3 plus vitamin E and vitamin C plus zinc supplementations on plasma lipids and lipoprotein profile in postmenopausal women with type 2 diabetes
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MR Mahmoodi   , M Kimiagar * , Y Mehrabi , A Rajab , M Hedayati |
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Abstract: (21523 Views) |
| Background and Objectives: Type 2 diabetes mellitus is associated with cardiovascular risk markers. Diabetic subjects with complications may have defective cellular antioxidant response to the oxidative stress generated by hyperglycemia. In this study we assessed the effects of omega-3 plus vitamin E and vitamin C plus zinc supplementations on serum lipids and lipoprotein profiles in postmenopausal women with type 2 diabetes and compared with control group values.
Materials and methods: In this double blind placebo controlled clinical trial, 75 postmenopausal women with type 2 diabetes participated from Iranian Diabetes Association in Tehran. Subjects were randomly assigned to one of three groups to take, daily, for 12 weeks, 1) 1.8 g omega-3 fatty acids plus 400 mg vitamin E (group 1), 2) five mg zinc plus 300 mg vitamin C (group 2), or 3) a placebo (group 3). The statistical tests used for data analysis were as follows: 1. analysis of variance for comparing the three groups at baseline and at the end of the period, and 2. repeated measure analysis of variance for adjustment of the other variables
Results: The compliance rate was 92% (69 subjects). While at baseline there were no significant differences in lipid and lipoprotein profile among the three groups, after the intervention a significant difference in plasma triglyceride concentration was found between group 1 and group 2 (138.3±5.7 vs. 180.3±18.0 mg/dl, respectively)(p= 0.038). However, the intervention brought about no significant differences in other lipids and lipoprotein profiles among the three groups.
Conclusion: The most pronounced effect of omega-3 plus vitamin E supplement was a reduction in plasma triglyceride as one of the most important metabolic syndrome components in group 1. Changes in the variables during intervention may be influenced by duration of diabetes. |
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| Keywords: Supplementation, Lipids, Lipoproteins, Postmenopausal women, Type 2 diabetes |
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Full-Text [PDF 281 kb]
(3706 Downloads)
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Article type: Research |
Subject:
Food Science
Received: 2009/12/15 | Published: 2009/12/15
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