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Investigating the Relationship between Dietary Total Antioxidant Capacity and Inflammatory Index and Anthropometric, Clinical, and Biochemical Parameters with Mortality in Patients with Liver Cirrhosis: A longitudinal Study
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M Shafiei    , Z Yari , E Fazeli Moghadam * |
| Assistant professor of Nutritional Sciences, Nutritional Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran , ztfazeli@yahoo.com |
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Abstract: (6 Views) |
Background and Objective: Diet plays a significant role in preventing, developing, and progressing liver cirrhosis. The present study investigated the relationship between dietary total antioxidant capacity, inflammatory index, and anthropometric, clinical, and biochemical parameters with mortality in patients with liver cirrhosis.
Materials and Methods: In this longitudinal study, 121 patients with liver cirrhosis were followed up for 60 months. Dietary intake was assessed using a food frequency questionnaire, and based on that, dietary total antioxidant capacity (DTAC) and dietary inflammatory index (DII) were calculated. Also, the nutritional status of the patients was assessed using the subjective global assessment (SGA), and anthropometric parameters were measured. The mortality risk as the main outcome was estimated using Cox regression models.
Results: After adjusting for confounding factors, the results showed that malnutrition was significantly associated with an increased mortality risk. The association of anthropometric measurements with mortality showed an inverse and significant association between mid-arm circumference (HRT3 vs T1 = 0.28, P = 0.021) and mid-arm muscle circumference (HRT3 vs T1 = 0.24, P = 0.022). The results also showed that the mortality risk decreased significantly with increasing DTAC (HRT3 vs T1 = 0.22, P = 0.037) and increased significantly with increasing DII (HRT3 vs T1 = 4.8, P = 0.029).
Conclusion: An anti-inflammatory diet with high total antioxidant capacity can reduce the mortality risk in patients with cirrhosis. Improving nutritional status, reducing malnutrition, and maintaining muscle mass are also associated with reducing the patients’ mortality risk. |
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| Keywords: Liver cirrhosis, Mortality, Total antioxidant capacity, Dietary inflammatory index |
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Full-Text [PDF 742 kb]
(2 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2024/12/21 | Accepted: 2025/01/12 | Published: 2025/10/12
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Shafiei M, Yari Z, Fazeli Moghadam E. Investigating the Relationship between Dietary Total Antioxidant Capacity and Inflammatory Index and Anthropometric, Clinical, and Biochemical Parameters with Mortality in Patients with Liver Cirrhosis: A longitudinal Study. Iranian J Nutr Sci Food Technol 2025; 20 (3) :1-12 URL: http://nsft.sbmu.ac.ir/article-1-3954-en.html
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