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Evaluation of the Preventive Effect of Lepidium draba Extract on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats
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T Ahmadi   , E Askari , S Yarahmadi , E Fazeli moghadam *  , M Rashidipoor |
| , ztfazeli@yahoo.com |
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Abstract: (22 Views) |
Background and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Epidemiological evidence indicates an inverse association between the intake of fruit- and vegetable-rich diets, due to their high phenolic acid content, and the incidence of MASLD. Lepidium draba L. (commonly known as Mocheh) is rich in polyphenolic compounds and may exhibit protective effects against liver injury. This study aimed to investigate the preventive effects of Mocheh extract on the development of MASLD in rats fed a high-fat diet.
Materials & Methods: In this experimental study, 24 male rats were randomly assigned to four groups: control (standard diet), MASLD (high-fat diet), M (standard diet + oral gavage of 400 mg/kg Mocheh extract), and MASLD+M (high-fat diet + oral gavage of Mocheh extract). After 12 weeks, biochemical parameters including fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), Low-Density Lipoprotein (LDL), High-Density Lipoprotein cholesterol (HDL), and the activities of Aspartate Transaminase (AST) and Alanine aminoTransferase (ALT) enzymes were measured in serum samples. Additionally, liver tissue samples were analyzed for catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and malondialdehyde (MDA) levels.
Results: Mocheh extract significantly reduced LDL (p = 0/0370), MDA (p = 0/0338) levels, and AST (p= 0/0112) and ALT (p = 0/0153) activities, while significantly enhancing SOD (p = 0/0175) and CAT (p = 0/0165) activities. Histopathological evaluations confirmed reduced oxidative liver damage in the Mocheh-treated groups.
Conclusion: Given its notable antioxidant and anti-inflammatory properties—attributable to its phenolic and flavonoid compounds—Mocheh extract may serve as a promising preventive agent against liver injury induced by a high-fat diet.
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| Keywords: MASLD, Herbal drugs, Liver enzymes, polyphenols, Mocheh |
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Full-Text [PDF 837 kb]
(14 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2025/04/30 | Accepted: 2025/06/29
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