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The Association Between Micronutrient Patterns and Lung Cancer Risk Based on Age of Onset in Adults in Tehran: A Case-Control Study
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M Mameghanian    , M Mohammadzadeh , A Bahrami , S Seyfi* , M Bajhan , Z Sheykhi , H Rahmani Seraji , E Hejazi * |
| , ehsanhejazi@gmail.com |
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Abstract: (9 Views) |
Background and Objective: Lung cancer is the most common cancer in the world. Limited studies have examined the association between micronutrient patterns and lung cancer risk. Considering the importance of identifying these patterns in developing preventive strategies and public health policies, this study aimed to investigate the relationship between micronutrient patterns and lung cancer risk by age at onset in an Iranian population.
Materials and Methods: This hospital-based case-control study included 135 cases and 237 controls. General information, physical activity, and food frequency questionnaires were completed, and anthropometric indices were measured. Micronutrient patterns were identified using principal component analysis (PCA) based on 33 micronutrients. Associations between the derived patterns and lung cancer risk were assessed using multivariable logistic regression.
Results: Among the four identified micronutrient patterns, the fourth micronutrient pattern, labeled the “fiber and antioxidant” pattern—characterized by insoluble fiber, soluble fiber, vitamin E, α-tocopherol, β-cryptoxanthin, and lycopene—was significantly associated with reduced lung cancer risk OR=0.22 (CI 95%=0.10-0.46, P<0.001). Additionally, this model can significantly reduce the incidence of lung cancer in individuals aged 55 years and older—a group at higher risk of developing the disease (OR = 0.13, 95% CI = 0.04–0.43, P < 0.001).
Conclusion: Given the age-related increase in lung cancer incidence, the fourth micronutrient pattern referred to as the fiber and antioxidant pattern, appears to have greater preventive potential compared with other patterns. Further studies with larger populations are warranted to confirm these findings. |
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| Keywords: Micronutrient patterns, Lung cancer, Factor analysis, Diet |
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Full-Text [PDF 896 kb]
(3 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2025/09/17 | Accepted: 2025/11/19
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