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Integrating the Fatty Liver Index into Primary Care: A Low-Cost Strategy for Early Identification of Chronic Kidney Disease Risk in Iran
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S Bazmi   , M Farjam , J Mirzay Razzaz * , Matin Sepehrinia , R Homayounfar |
| , jmrazaz2018@gmail.com |
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Abstract: (2 Views) |
Chronic kidney disease and metabolic dysfunction-associated steatotic liver disease are growing public health challenges and share common risk factors, including obesity, diabetes, hypertension, dyslipidemia, and chronic inflammation. This policy brief is based on the Fasa adult cohort study, which examined the association of the Fatty Liver Index and metabolic dysfunction-associated steatotic liver disease with kidney function and incident chronic kidney disease among Iranian adults.
The findings showed that the Fatty Liver Index and metabolic dysfunction-associated steatotic liver disease may serve as early warning markers for chronic kidney disease risk. In the Fasa study, individuals with metabolic dysfunction-associated steatotic liver disease had approximately 55% higher odds of chronic kidney disease at baseline and a 35% higher risk of incident chronic kidney disease during five years of follow-up. Each 10-unit increase in the Fatty Liver Index was also associated with a significant decline in kidney function. The findings further indicated that region-specific and sex-specific Fatty Liver Index cutoffs showed a more precise and stable association with chronic kidney disease risk in the Iranian population compared with the conventional European cutoff.
Based on these findings, integrating automatic Fatty Liver Index calculation into electronic health records, developing a joint screening and care algorithm for metabolic dysfunction-associated steatotic liver disease and chronic kidney disease, and strengthening lifestyle-oriented care for high-risk individuals may support early identification and help reduce the risk of chronic kidney disease onset or progression. |
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| Keywords: Fatty Liver Index, Chronic kidney disease, Metabolic dysfunction-associated steatotic liver disease |
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Full-Text [PDF 768 kb]
(5 Downloads)
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Article type: Brief Policy |
Subject:
nutrition
Received: 2026/05/25 | Accepted: 2026/01/30 | Published: 2026/06/1
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