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The effects of monounsaturated fatty acid-rich diet on the serum levels of visfatin, insulin and interleukin-6 in overweight women
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Farhad Haghighatdoost   , MJ Hosseinzadeh * , A Kabiri , A Esmaillzadeh |
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Abstract: (11771 Views) |
| Background and Objective:Little information is available on the effects of monounsaturated fatty acid-rich (MUFA-rich) diets on the serum adipocytokine levels. The objective of this study was to determine the effects of a MUFA-rich diet on the serum levels of insulin, visfatin and IL-6 in overweight women (25.0≥ BMI ≥ 2.9.9).
Materials and Methods:This randomized cross-over clinical trial included 17 overweight women aged 20-50 years with a mean BMI of 27.6±2 kg/m2. The participants were randomly assigned to one of two groups consuming either a saturated fat-rich (SFA-rich 16% SFA and 8% MUFA) or a MUFA-rich (16% MUFA and 8% SFA) diet for 6 weeks, with a 2-week washout period between the 2 periods. The percentages of energy derived from the other macronutrients were similar in the two diets. Biochemical assessments were done at the beginning and at the end of each period. Paired t-test was used for statistical analysis.
Results: The mean proportions of MUFA intakes were 13% and 7% of the total energy intake for MUFA- and SFA-rich diets, respectively, the corresponding values for SFA being 8.5% and 14%. The mean changes in the serum visfatin, insulin and IL-6 levels were not significantly different between the two diet periods however, for serum visfatin levels, the difference (0.7± 0.5 vs 0.4± 0.4 nanogr/ml) was marginally significant (P=0.08). Adjustment for potential confounders did not alter these findings (P=0.1).
Conclusion:The difference between the two diets as regards their effects on the serum insulin and adipocytokine levels did not reach statistical significanec (it was only marginal). We recommend conducting long-term interventional studies with larger sample sizes to be able to draw more definite conclusions.
Keywords: Visfatin, Overweight, Monounsaturated fatty acids, Insulin, Interleukin-6 |
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| Keywords: Visfatin, Overweight, Monounsaturated fatty acids, Insulin, Interleukin-6 |
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Full-Text [PDF 295 kb]
(2381 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2011/12/18 | Published: 2012/01/15
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