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Effects of L-carnitine supplement on serum amyloid A and vascular inflammatory factors in hemodialysis patients
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F Hakeshzadeh   , M Tabibi * , M Hedayati , T Malakoutian |
| , h.tabibi@nnftri.ac.ir |
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Abstract: (13716 Views) |
| Background and objectives: Cardiovascular diseases are the most important cause of death in patients with chronic renal failure, including hemodialysis patients. Systemic inflammatory factors, including serum amyloid A and vascular inflammatory factors, are two major risk factors for atherosclerosis in these patients. The present study was designed to investigate the effects of L-carnitine supplement on serum amyloid A and vascular inflammatory factors in hemodialysis patients.
Materials and methods: The study was a double-blind randomized clinical trial. Fourty-two hemodialysis patients (25 females and 17 males) were randomly assigned to either carnitine or a placebo group. The patients in the carnitine group received a vial containing 1000 mg oral L-carnitine daily for 12 weeks, while the placebo group received a corresponding placebo vial. At the baseline and the end of the 12th week of the study, 5 ml blood was collected from each patient and each control individual after a 12- to 14-hour fast before dialysis and serum amyloid A, free carnitine, sICAM-1, sICAM-2, sVCAM-1, sE-selectin, sP-selectin and ox-LDL levels were measured.
Results: The mean serum free carnitine concentration increased by 150% in the carnitine group at the end of the 12th week as compared to the baseline value (P<0.001), while the serum amyloid A level decreased by 32% (P<0.001). No significant changes were observed in the serum concentrations of free carnitine or serum amyloid A in the control group. In addition, no significant differences were observed between the two groups in the mean changes of serum sICAM-1, sICAM-2, sVCAM-1, sE-selectin, sP-selectin or ox-LDL concentrations.
Conclusion: The results of the present study indicate that L-carnitine supplement can reduce serum
amyloid A concentration, as a systemic inflammatory indicator, in hemodialysis patients and may play an effective role in preventing cardiovascular diseases in these patients, while it has no effect on the serum vascular inflammatory factors. |
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| Keywords: L-carnitine, Hemodialysis, Serum amyloid A, Vascular inflammation |
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Full-Text [PDF 260 kb]
(2446 Downloads)
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Article type: Research |
Subject:
Food Science
Received: 2009/01/11 | Published: 2008/12/15
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