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Association between Vitamin D Intake and Risk of Breast Cancer in Iranian Women: A Case-control Study
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Y Jamshidi Naeini   , ME Akbari , M Abdollahi , M Ajami , H Davoodi * |
| National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences |
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Abstract: (8629 Views) |
| Background and Objectives: Studies suggest a possible protective role of vitamin D against breast cancer. This study aimed to assess the relationship between vitamin D intake and risk of breast cancer in Iranian women.
Materials and Methods: A total of 135 new cases of breast cancer and 135 matched controls were included in the study. The data on breast cancer risk factors, sunlight exposure and use of vitamin D supplements were obtained through demographic questionnaire. To measure the intake of energy, macronutrients, calcium, and vitamin D we used a 168-item semi-quantitative food frequency questionnaire.
Results: The mean dietary intake of vitamin D in the cases was significantly lower than the control group (24 vs. 30.56 IU/day) (P=0.001). The risk of developing breast cancer was 2.5 times (61%) lower for those in the highest quartile of dietary intake of vitamin D compared to those in the first quartile (OR=0.392, 95%CI=0.196-0.784). This inverse association was marginally significant in the premenopausal women (OR=0.39, 95%CI=0.151-1.006), but not in the postmenopausal women. Overall, the total intake of vitamin D from foods and supplements was not associated with breast cancer risk, in both the premenopausal and postmenopausal women.
Conclusion: Dietary intake of vitamin D may have a protective role against breast cancer, especially in premenopausal women.
Keywords: Breast cancer, Dietary vitamin D intake, Total vitamin D intake |
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| Keywords: Breast cancer, Dietary vitamin D intake, Total vitamin D intake |
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Full-Text [PDF 215 kb]
(4266 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/09/20 | Accepted: 2014/12/7 | Published: 2015/03/18
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