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:: Volume 11, Issue 1 (Spring 2016) ::
Iranian J Nutr Sci Food Technol 2016, 11(1): 1-10 Back to browse issues page
The Effect of Synbiotic Gaz Fortified with Beta-carotene Consumption on Glycemic Control and Blood Lipids of Patients with Type 2 Diabetes
F Sayyedi , Z Asemi * , M Goli , F Bahmani , S Alizadeh , A Esmaillzadeh
Kashan University of Medical Sciences , asemi_r@yahoo.com
Abstract:   (7828 Views)

Background & Objectives: Recent evidence suggests that antioxidants and synbiotics intake due to the effect on inflammatory cytokines and oxidative stress may affect the glycemic control and blood lipids of diabetic patients. The aim of study was to investigate the effect of synbiotic Gaz fortified with beta-carotene consumption on metabolic profile among patients with type 2 diabetes (T2D).

Materials and Methods: This randomized double-blinded cross-over controlled clinical trial was conducted among 51 patients with T2D aged 35-70 y. After a 2-wk run-in period, the individuals were randomly assigned to consume either a synbiotic Gaz fortified with beta-carotene (n=51) or control food (n=51) for 6 weeks. A 3-week washout period was applied; then the subjects were crossed over to the alternate treatment arm for an additional 6 weeks. The synbiotic Gaz fortified with beta-carotene contained a probiotic viable and heat-resistance strain Lactobacillus sporogenes (1×107 CFU), 0.15 g inulin as prebiotic and 0.04 g beta-carotene. The control food (the same substance without probiotic bacteria, prebiotic inulin and beta-carotene) was packed in identical 7-gram packages. The patients were asked to consume the synbiotic or control Gaz three times a day. Fasting blood samples were taken at baseline and after 6-wk phase of intervention to measure the metabolic profile.

Results: After 6 weeks of intervention, synbiotic Gaz fortified with beta-carotene consumption compared with the control Gaz has resulted in a significant decrease in serum insulin (changes from baseline:
 -1.00±7.90 vs. +3.68±6.91 µIU/mL, P=0.002), HOMA-IR (-0.73±3.96 vs. +1.82±4.09, P=0.002), HOMA-B (-0.52±19.75 vs. +8.71±17.15, P=0.01), triglycerides (-2.86±49.53 vs. +20.14±50.10 mg/dL, P=0.02), VLDL-cholesterol (-0.57±9.90 vs. +4.03±10.02 mg/dL, P=0.02) and total-/HDL-cholesterol ratio
(-0.01±1.08 vs. +0.64±0.81, P=0.001).

Conclusion: In conclusion, consumption of the synbiotic Gaz fortified with beta-carotene for 6 weeks among the T2D patients compared with the control Gaz had beneficial effects on the serum insulin concentrations, insulin resistance, triglycerides, VLDL-cholesterol, and total-/HDL-cholesterol, but not on other biochemical profiles. 

Keywords: Synbiotic, Insulin resistance, Glycemic control, Blood lipid, Type 2 diabetes

Keywords: Synbiotic, Insulin resistance, Glycemic control, Blood lipid, Type 2 diabetes
Full-Text [PDF 219 kb]   (2184 Downloads)    
Article type: Research | Subject: nutrition
Received: 2015/06/7 | Accepted: 2015/09/6 | Published: 2016/04/6
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Sayyedi F, Asemi Z, Goli M, Bahmani F, Alizadeh S, Esmaillzadeh A. The Effect of Synbiotic Gaz Fortified with Beta-carotene Consumption on Glycemic Control and Blood Lipids of Patients with Type 2 Diabetes. Iranian J Nutr Sci Food Technol 2016; 11 (1) :1-10
URL: http://nsft.sbmu.ac.ir/article-1-1938-en.html


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Volume 11, Issue 1 (Spring 2016) Back to browse issues page
Iranian Journal of  Nutrition Sciences and Food  Technology
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