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Association of some dietary intakes, anthropometric measurements and insulin resistance with the relative P53 gene expression in visceral and subcutaneous adipose tissue in obese, and non-obese subjects
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M Hajizadeh oghaz    , G Kadkhoda , M Zarkesh , N Hosseinzadeh , A Saidpour * , M Hedayati |
| Shahid Beheshti University of Medical Sciences , atoosa.saidpour@gmail.com |
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Abstract: (2193 Views) |
Background and Objectives: The P53 is one of the genes involved in weight management. This study investigated associations of dietary intakes, anthropometric measurements and insulin resistance with relative P53 gene expressions.
Materials & Methods: Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were collected from 151 individuals, aging nearly 40 years, who underwent elective abdominal surgeries. The participants were grouped based on their body mass index (BMI) as obese (BMI > 30 kg/m2) and non-obese (BMI = 18.5–30 kg/m2). Relative P53 mRNA expressions in VAT and SAT were studied using real-time polymerase chain reaction (PCR). Before the surgery, dietary intake, BMI, waist and hip circumference and HOMA-IR were measured.
Results: Relative P53 mRNA expressions of the obese participants were significantly higher than those of non-obese participants only for VAT (p = 0.008). In VAT of obese participants, positively significant associations were seen between P53 gene expression and body weight (β = 0.909, p = 0.018) and the body mass index (BMI) (β = 0.262, p = 0.014). Positively significant associations were observed between the energy intake and relative P53 gene expression in VAT (β = 3.230, p = 0.020) and SAT (β = 3.336, p = 0.014) of obese participants.
Conclusion: Results demonstrated that higher body weight, BMI and calorie intake might be effective in creating stressful conditions, which might include associations with the induction of relative p53 gene expression. |
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| Keywords: P53 gene, Anthropometric measurements, Insulin resistance, Dietary intake, Obesity |
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Full-Text [PDF 686 kb]
(1257 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2020/02/3 | Accepted: 2020/05/12 | Published: 2020/06/27
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