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:: Volume 16, Issue 4 (Winter 2022) ::
Iranian J Nutr Sci Food Technol 2022, 16(4): 9-18 Back to browse issues page
Effects of Aerobic Training with Ginger Consumption on Plasma Levels of Adipokine Glipican-4 and Hepatokine Fetuin- A in Rats with Non-alcoholic Fatty Livers
B Zandi , B Abedi *
Islamic Azad University
Abstract:   (294 Views)
Background and Objectives: Fatty liver is one of the most common diseases as a result of obesity and overweight. Recently, much attentions have been paid to the role of herbs in the treatment of these disease. The purpose of the present study was to investigate effects of aerobic exercise with ginger consumption on adipokine glypican-4 and hepatokine fetuin-A in mice with non-alcoholic fatty livers.
 Materials & Methods: This was an experimental study. Forty rats with non-alcoholic fatty liver disease due to high-fat diets were randomly divided into four major groups of control, ginger, aerobic exercise and aerobic exercise and ginger. Exercises were carried out for eight weeks, five days a week. Physical activity was carried out as aerobic exercise using treadmill at a speed of 20–25 m per min, equivalent to 60–65% of the maximum oxygen consumption. Exercise was carried out for 60 min a day and the treadmill speed increased every week. Ginger was consumed at a dose of 100 mg/kg body weight daily (once a day at 8 am).
Results: Results showed that exercise caused significant increases in glycipane-4 (p = 0.001), but the effects of ginger
(p = 0.64) and ginger and exercise were not significant (p = 0.95). Furthermore, exercise resulted in significant decreases in fetuin-A (p = 0.001); however, effects of ginger (p = 0.12) and exercise and ginger were not significant
(p = 0.69).
Conclusion: Aerobic exercise is likely to improve non-alcoholic fatty liver disease via improvements in insulin signaling, increasing glycophane-4 and decreasing fetuin-A.
Keywords: Fatty liver, Glycipane-4, Fetuin-A, Aerobic exercise, Ginger
Full-Text [PDF 578 kb]   (44 Downloads)    
Article type: Research | Subject: nutrition
Received: 2020/12/11 | Accepted: 2021/07/28 | Published: 2021/12/14
1. FarzanegiP, Dana A, Ebrahimpoor Z, Asadi M, Azarbayjani MA. Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. Eur J Sport Sci. 2019 Aug;19(7):994-1003. [DOI:10.1080/17461391.2019.1571114]
2. Bayard M, Holt J, Boroughs E. Nonalcoholic fatty liver disease. American family physician. 2006;73(11): 1961-8.
3. Devries M, Samjoo I, Hamadeh M, Tarnopolsky M. Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. Obesity and metabolism. 2009;6(4):49-50. [DOI:10.14341/2071-8713-4882]
4. Katsiki N, Mantzoros C, Mikhailidis DP. Adiponectin, lipids and atherosclerosis. Current opinion in lipidology. 2017;28(4):347-54. [DOI:10.1097/MOL.0000000000000431]
5. Gesta S, Blüher M, Yamamoto Y, Norris AW, Berndt J, Kralisch S, et al. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proceedings of the National Academy of Sciences. 2006;103(17):6676-81. [DOI:10.1073/pnas.0601752103]
6. Ussar S, Bezy O, Blüher M, Kahn CR. Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine. Diabetes. 2012;61(9):2289-98. [DOI:10.2337/db11-1395]
7. Ix JH, Sharma K. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. Journal of the American Society of Nephrology. 2010;21(3):406-12. [DOI:10.1681/ASN.2009080820]
8. Reinehr T, Roth CL. Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss. The Journal of Clinical Endocrinology & Metabolism. 2008;93(11):4479-85. [DOI:10.1210/jc.2008-1505]
9. Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring H-U, et al. Fetuin-A induces cytokine expression and suppresses adiponectin production. PloS one. 2008;3(3):e1765. [DOI:10.1371/journal.pone.0001765]
10. Malin SK, Mulya A, Fealy CE, Haus JM, Pagadala MR, Scelsi AR, et al. Fetuin-A is linked to improved glucose tolerance after short-term exercise training in non-alcoholic fatty liver disease. American Journal of Physiology-Heart and Circulatory Physiology. 2013. [DOI:10.1152/japplphysiol.00237.2013]
11. Malin SK, Del Rincon JP, Huang H, Kirwan JP. Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity. Medicine and science in sports and exercise. 2014;46(11):2085. [DOI:10.1249/MSS.0000000000000338]
12. Hashida R, Kawaguchi T, Bekki M, Omoto M, Matsuse H, Nago T, et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. Journal of hepatology. 2017;66(1):142-52. [DOI:10.1016/j.jhep.2016.08.023]
13. Black CD, O'Connor PJ. Acute effects of dietary ginger on quadriceps muscle pain during moderate-intensity cycling exercise. International journal of sport nutrition and exercise metabolism. 2008;18(6):653-64. [DOI:10.1123/ijsnem.18.6.653]
14. Hafez DA. Effect of extracts of ginger goots and cinnamon bark on fertility of male diabetic rats. Am Sci 2010; 6(10): 940-7.
15. Amin A, Hamza AA. Effects of Roselle and Ginger on cisplatin induced reproductive toxicity in rats. Asian J Androl 2006; 8(5): 607-12. [DOI:10.1111/j.1745-7262.2006.00179.x]
16. Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz S. Ginger supplementation in nonalcoholic fatty liver disease: a randomized, doubleblind, placebo-controlled pilot study. Hepat Mon 2016; 16(1). [DOI:10.5812/hepatmon.34897]
17. Suttner SW, Schmidt CC, Boldt J, Huttner I, Kumle B, Piper S, et al. Low-flow desflurane and sevoflurane anesthesia minimally affect hepatic integrity and function in elderly patients. Anesth Analg 2000; 91(1): 206-12. [DOI:10.1213/00000539-200007000-00039]
18. Hoydal, MA, Wisloff, U, Kemi, OJ, et al. Running speed and maximal oxygen uptake in rats and mice: Practical implications for exercise training. Eur J Cardiovasc Prev Rehabil 2007; 14: 753-760. [DOI:10.1097/HJR.0b013e3281eacef1]
19. Zar A, Hoseini‎ A, Ahmadi F, Rezaei M. Effects of Ginger together with Swimming Training on Blood Fat Profiles in Adult Diabetic Rats with Streptozotocin. Iranian Journal of Nutrition Sciences & Food Technology. 2016;11(2):65-74.
20. Yoo H, Hwang S, Cho G, Hong H, Choi H, Hwang T, et al. Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. The Journal of Clinical Endocrinology & Metabolism. 2013;98(7):2897-901. [DOI:10.1210/jc.2012-4297]
21. Zhang L-Y, Liu T, Teng Y-Q, Yao X-Y, Zhao T-T, Lin L-Y, et al. Effect of a 12-week aerobic exercise training on serum fetuin-A and adipocytokine levels in type 2 diabetes. Experimental and Clinical Endocrinology & Diabetes. 2018;126(08):487-92. [DOI:10.1055/s-0043-115904]
22. Blumenthal JB, Gitterman A, Ryan AS, Prior SJ. Effects of exercise training and weight loss on plasma Fetuin-a levels and insulin sensitivity in overweight older men. Journal of diabetes research. 2017;2017. [DOI:10.1155/2017/1492581]
23. Pérez-Sotelo D, Roca-Rivada A, Larrosa-García M, Castelao C, Baamonde I, Baltar J, et al. Visceral and subcutaneous adipose tissue express and secrete functional alpha2hsglycoprotein (fetuin a) especially in obesity. Endocrine. 2017;55(2):435-46. [DOI:10.1007/s12020-016-1132-1]
24. Schultes B, Frick J, Ernst B, Stefan N, Fritsche A. The effect of 6-weeks of aerobic exercise training on serum fetuin-A levels in non-diabetic obese women. Experimental and clinical endocrinology & diabetes. 2010;118(10):754-6. [DOI:10.1055/s-0030-1253418]
25. Lee S, Norheim F, Gulseth HL, Langleite TM, Kolnes KJ, Tangen DS, et al. Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise. Physiological reports. 2017;5(5). [DOI:10.14814/phy2.13183]
26. Trepanowski J, Mey J, Varady K. Fetuin-A: a novel link between obesity and related complications. International Journal of Obesity. 2015;39(5):734. [DOI:10.1038/ijo.2014.203]
27. Abdel-Azeem AS, Hegazy AM, Ibrahim KS, Farrag A-RH, El-Sayed EM. Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. Journal of dietary supplements. 2013;10(3):195-209. [DOI:10.3109/19390211.2013.822450]
28. Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of complementary and integrative medicine. 2015;12(2):165-70. [DOI:10.1515/jcim-2014-0021]
29. Mozaffari-Khosravi H, Talaei B, Jalali B-A, Najarzadeh A, Mozayan MR. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complementary therapies in medicine. 2014;22(1):9-16. [DOI:10.1016/j.ctim.2013.12.017]
30. Mohamed OI, El-Nahas AF, El-Sayed YS, Ashry KM. Ginger extract modulates Pb-induced hepatic oxidative stress and expression of antioxidant gene transcripts in rat liver. Pharmaceutical biology. 2016;54(7):1164-72. [DOI:10.3109/13880209.2015.1057651]
31. Nwozo SO, Osunmadewa DA, Oyinloye BE. Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats. Journal of integrative medicine. 2014;12(1):59-65. [DOI:10.1016/S2095-4964(14)60006-6]
32. Abdulaziz Bardi D, Halabi MF, Abdullah NA, Rouhollahi E, Hajrezaie M, Abdulla MA. In vivo evaluation of ethanolic extract of Zingiber officinale rhizomes for its protective effect against liver cirrhosis. BioMed research international. 2013;2013:918460. [DOI:10.1155/2013/918460]
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Zandi B, Abedi B. Effects of Aerobic Training with Ginger Consumption on Plasma Levels of Adipokine Glipican-4 and Hepatokine Fetuin- A in Rats with Non-alcoholic Fatty Livers. Iranian J Nutr Sci Food Technol. 2022; 16 (4) :9-18
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Volume 16, Issue 4 (Winter 2022) Back to browse issues page
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