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The anticancer effects of flavonoids: involvment of PI3K/ Akt signaling pathway
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R Shahbazi   , H Davoodi * , S Esmaeili |
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Abstract: (12257 Views) |
| Flavonoids as a group of polyphenolic compounds, have recently gained considerable attention because of their potential beneficial effects on human health. A number of studies have indicated chemopreventive effects of flavonoids on cancer cells via suppression of PI3K/Akt pathway. Deregulation of PI3-Kinase/Akt pathway trigger a cascade of responses, from cell growth and proliferation to survival and motility, that drive tumor progression. In this article the anti carcinogenic features of flavonoids through involvement of PI3K/Akt pathway have been reviewed.
Pubmed, Sciencedirect, Springer and Google scholar databases were searched in order to achieve the desired articles. Cellular and animal studies that have been conducted from 1995 till 2012 were recruited in this investigation.
Researches indicate the anticancer effects of flavonoids through suppression of PI3k activity and subsequent inhibition of Akt activity. Inactivation of this pathway leads to subsequent inhibition of other signaling pathway such as mTOR and NF-kB. The suppression of mTOR and NF-kB cause to decrease of proliferation and cell growth as well as inhibit cell invasion and metastasise. Apoptosis Also increase via upregulation of proapoptotic proteins and downregulation of antiapoptotic proteins. Furthermore, repression of PI3K/ Akt pathway in endothelial cells blocks angiogenesis.
Taken together, flavonoids as potent chemopreventive agents, through downregulation of PI3k/Akt signaling pathway, can possess effective role in cancer prevention and treatment. So, application of flavonoids as supplementary treatment with medicine therapy is suggested, but more researches in cellular and animal model are necessary.
Keywords: Flavonoids, PI3k / Akt pathway, Apoptosis, Angiogenesis, Proliferation, Metastasis |
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| Keywords: Flavonoids, PI3k / Akt pathway, Apoptosis, Angiogenesis, Proliferation, Metastasis |
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Full-Text [PDF 314 kb]
(7982 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2013/02/6 | Accepted: 2013/10/15 | Published: 2013/10/15
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