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:: Volume 15, Issue 4 (Winter 2021) ::
Iranian J Nutr Sci Food Technol 2021, 15(4): 11-19 Back to browse issues page
Effects of Resistance Training with Aqueous Extract of Garlic (Allium sativum L.) on Relative Expression Levels of CTRP3 and IL-6 in Adipose Tissues and Insulin Resistance in Streptozotocin-Diabetic Rats
E Sadeghpour Firozabadi , A Abdi * , A Abbassi Daloii
Islamic Azad University , a.abdi58@gmail.com
Abstract:   (2096 Views)
Background and Objectives: Since adipokines affect insulin sensitivity and inflammation, regulation of adipokines may play a critical role in etiology of insulin resistance, which is associated to type 2 diabetes. The aim of this study was to investigate effects of resistance training with use of aqueous extract of garlic (Allium sativum L.) on relative expression levels of CTRP3 and IL-6 and insulin resistance in streptozotocin-diabetic rats.
 Materials & Methods: In this experimental study, 40 male Wistar rats were divided into five major groups of control-normal, diabetes, diabetes-training, diabetes-garlic and diabetes-training-garlic groups. Diabetes was induced in rats using intraperitoneal administration of a single dose of streptozotocin (60 mg/kg). Training group carried out resistance training for eight weeks (five days per week). The resistance training protocol consisted of climbing a 1-m ladder with a weight attached to the tail sleeve. A dose of 1 ml of garlic extract/100 g body weight was orally administered daily to rats.
Results: Results of the present study showed decreases in CTRP3 relative expression (p = 0. 001) and increases in IL-6 protein (p = 0.001) and HOMA-IR (p = 0. 001) in diabetes groups, compared to control-normal group. The CTRP3 relative expression of diabetes-training (p = 0.037), diabetes-garlic (p = 0.042) and diabetes-training-garlic (p = 0. 001) groups showed significant increases, compared to diabetes group. Furthermore, significant decreases were seen in IL-6 levels in diabetes-training (p = 0.015), diabetes-garlic (p = 0.021) and diabetes-training-garlic (p = 0. 001) groups, compared to diabetes group. The HOMA-IR levels of diabetes-training (p = 0.003), diabetes-garlic (p = 0.049) and diabetes-training-garlic (p = 0.002) groups decreased significantly, compared to diabetes group.
Conclusion: In conclusion, increased CTRP3 expression and decreased IL-6 adipose tissues followed by resistance training and garlic extract use are associated to decreased insulin resistance in diabetic rats.
Keywords: Exercise, Garlic, Inflammation, CTRP3, Insulin resistance, Diabetes
Full-Text [PDF 772 kb]   (799 Downloads)    
Article type: Research | Subject: nutrition
Received: 2020/08/10 | Accepted: 2020/09/27 | Published: 2020/12/20
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Sadeghpour Firozabadi E, Abdi A, Abbassi Daloii A. Effects of Resistance Training with Aqueous Extract of Garlic (Allium sativum L.) on Relative Expression Levels of CTRP3 and IL-6 in Adipose Tissues and Insulin Resistance in Streptozotocin-Diabetic Rats. Iranian J Nutr Sci Food Technol 2021; 15 (4) :11-19
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Volume 15, Issue 4 (Winter 2021) Back to browse issues page
Iranian Journal of Nutrition Sciences and Food Technology
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