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Efficacy of Vitamin D-fortified Yogurt drink (doogh) on Improvement of Endothelial Biomarkers in Subjects with Type 2 Diabetes: A Randomized Clinical Trial
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P Davallou   , S Shab-Bidar , TR Neyestani * , A Djazayery |
| Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute (NNFTRI), Shahid Beheshti University of Medical Sciences , neytr@yahoo.com |
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Abstract: (7551 Views) |
| Background and Objectives: In this study, the effect of improvement of vitamin D status on glycemic status, lipid profile and endothelial biomarkers in T2D subjects was investigated.
Materials and Methods: Subjects with T2D were randomly allocated to one of the two groups to receive either plain yogurt drink (PYD containing 170 mg calcium and no vitamin D/250 mL, n= 50) or vitamin D3-fortified yogurt drink (FYD containing 170 mg calcium and 500 IU/250 mL, n = 50) twice a day for 12 weeks. Anthropometric measures, glycemic status, lipid profile, body fat mass (FM) and endothelial biomarkers were evaluated at the beginning and after the 12-week intervention period.
Results: Intervention resulted in significant differences in changes of endothelin-1, E-selectin and MMP-9 concentrations in FD compared to PD (-0.35 ± 0.63 versus -0.03 ± 0.55, P= 0.028 -3.8 ± 7.3 versus 0.95 ± 8.3, P = 0.003 and -2.3 ± 3.7 versus 0.44 ± 7.1 ng/mL, respectively, P < 0.05 for all). Even after controlling for changes of QUICKI, FM and waist circumference remained significant for endothelin-1 and MMP-9 (P = 0.009 and P = 0.005, respectively).
Conclusions: Ameliorated vitamin D status was accompanied by improved glycemic status, lipid profile and endothelial biomarkers in T2D subjects. The research findings suggest both direct and indirect ameliorating effects of vitamin D on the endothelial biomarkers.
Keywords: Vitamin D, Endothelial, Blood glucose, Lipid profiles |
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| Keywords: Vitamin D, Endothelial, Blood glucose, Lipid profiles |
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Full-Text [PDF 295 kb]
(2138 Downloads)
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Article type: Research |
Subject:
nutrition
Received: 2014/12/19 | Accepted: 2015/06/14 | Published: 2015/09/26
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