Background and Objective: Excessive consumption of added sugar has become a critical crisis in Tabriz, serving as one of the primary drivers of non-communicable diseases (NCDs). This study aims to analyze the process of agenda-setting and how the issue of reducing sugar consumption entered the policymakers' agenda, utilizing Kingdon's Multiple Streams Framework (MSF). Methodology: Utilizing Kingdon's Multiple Streams Framework, this study analyzes the convergence of the problem, policy, and politics streams in Tabriz between 2000 and 2023 (1379–1402 AH). It explains how policy windows were opened and examines the pivotal role of policy entrepreneurs within this domain. Findings: In the problem stream, a sharp spike in diabetes prevalence (from 8.2% to 10.9%) alongside rising hospitalizations among youth transformed the issue into a public emergency. In the policy stream, technical solutions—such as taxing high-sugar products and reforming school food environments—were developed. In the politics stream, the alignment of high-level national strategy documents with the advocacy of civil society organizations generated the necessary political will for action. Ultimately, a coalition of academic elites and municipal managers acted as policy entrepreneurs; by coupling these three streams between 2020 and 2022 (1399–1401 AH), they opened a policy window for structural reforms. Conclusion: Successfully reducing sugar consumption in Tabriz demands intersectoral coordination among the municipality, the Ministry of Education, and healthcare authorities. Implementing policy options such as a 20% tax on sugar-sweetened products and imposing advertising restrictions, paired with local empowerment, can serve as a national model for controlling non-communicable diseases.