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:: Volume 17, Issue 4 (Winter 2023) ::
Iranian J Nutr Sci Food Technol 2023, 17(4): 1-10 Back to browse issues page
Association of Dietary Phytochemical Index and Anthropometric Risk Factors with Non-alcoholic Fatty Liver Disease in People with Diabetes
S Soltanieh , M Salavatizadeh, H Poustchi, Z Yari, A Mansour, M.E Khamseh, M Malek, F Alaei-Shahmiri, A Hekmatdoost *
Prof, Department of Clinical Nutrition & Dietetics, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran , a_hekmat2000@yahoo.com
Abstract:   (189 Views)
Background and Objectives: High prevalence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus results in deleterious complications and morbidities. Therefore, the aim of this study was to assess nutritional and anthropometrical risk factors in progression of non-alcoholic fatty liver disease in diabetic patients.
 Materials & Methods: Totally, 133 non-alcoholic fatty liver disease patients (CAP score > 270) and 67 controls (CAP score < 270) were selected from the patients with type 2 diabetes mellitus in a clinic. Dietary phytochemical index was calculated via data from a validated 147-item FFQ. Body composition were measured using dual-energy X-ray absorptiometry. Other anthropometric indices and laboratory assays were used as well. Logistic regression models were used to estimate multivariable ORs.
Results: After adjustment for potential confounders, risk of progression for non-alcoholic fatty liver disease in participants with higher dietary phytochemical indices significantly decreased (OR = 0.35, 95% CI: 0.12–0.98, p = 0.048). After fully adjustment of covariates and independently from body mass index, positive associations were seen between the highest tertile of TLR (OR = 7.99, 95% CI: 2.43–26.26, p = 0.001), METS-VF (OR = 4.55, 95% CI: 1.46–14.2,
 p = 0.009) and risk of non-alcoholic fatty liver disease.

Conclusion: Findings of this study have demonstrated that phytochemical components of diet play protective roles against non-alcoholic fatty liver disease.  Moreover, TLR and METS-VF are addressed as novel estimators of central obesity as a risk factor for non-alcoholic fatty liver disease in diabetes.
 
Keywords: NAFLD, Diabetes, Dietary inflammatory index, Central obesity
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Article type: Research | Subject: nutrition
Received: 2022/10/28 | Accepted: 2022/11/9 | Published: 2022/12/24
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Soltanieh S, Salavatizadeh M, Poustchi H, Yari Z, Mansour A, Khamseh M, et al . Association of Dietary Phytochemical Index and Anthropometric Risk Factors with Non-alcoholic Fatty Liver Disease in People with Diabetes. Iranian J Nutr Sci Food Technol 2023; 17 (4) :1-10
URL: http://nsft.sbmu.ac.ir/article-1-3584-en.html


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Volume 17, Issue 4 (Winter 2023) Back to browse issues page
Iranian Journal of  Nutrition Sciences & Food  Technology
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